Observational studyJournal of the American Heart Association2026
Outcomes of Transcatheter Edge-to-Edge Repair in Potentially Favorable Candidates for Left Ventricular Assist Device: Evidence From the OCEAN-Mitral Registry.
Observational study in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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31 authors.
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Abstract
backgroundTranscatheter edge-to-edge repair of the mitral valve (M-TEER) has shown promising outcomes in patients with advanced heart failure and significant mitral regurgitation. Similarly, outcomes after left ventricular assist device (LVAD) implantation have improved in advanced heart failure with/without mitral regurgitation. However, the indication of M-TEER in favorable candidates for LVAD therapy remains unclear.
methodsPotentially favorable LVAD candidates were defined as patients with advanced heart failure and secondary mitral regurgitation who underwent M-TEER and were considered theoretically suitable for LVAD therapy based on data from the optimized catheter valvular intervention (OCEAN)-Mitral registry. Among this cohort, Cox proportional hazards regression analysis was performed to identify factors associated with cardiovascular death following M-TEER.
resultsA total of 3764 patients who underwent M-TEER were included. Of them, 129 were identified as potentially favorable LVAD candidates (mean age: 67 years; 67% men). Despite advanced heart failure, procedural success was 96%. The 1-year rate of cardiovascular death was 10.1%, increasing to 38.9% at 3 years. Baseline left ventricular end-diastolic diameter was independently associated with cardiovascular death (hazard ratio: 1.07 per 1-mm increase; 95% CI: 1.02-1.12;
conclusionsM-TEER can be safely performed even in potentially favorable LVAD candidates. However, long-term efficacy appears limited, particularly in those with advanced LV remodeling. Further studies are warranted to establish an optimal strategy, including the role of LVAD therapy versus M-TEER, for this high-risk population. REGISTRATION: URL: https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000027188.
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