Evidence map›Paper›PMID 41878815›Full record

ArticleCirculation research2026

Sodium Channel Isoform Diversity Underlies Chamber-Specific Cardiac Excitability.

Colin J Clark, Christian E Anderson, Alex Dou, Jason M Dierdorff, Jason D Galpin, Lionel Gissot, Samantha G Thompson, Hannah Choi, Jin-Young Yoon, Daniel T Infield and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Colin J Clark *Department of Molecular Physiology and Biophysics, University of Iowa (C.J.C., C.E.A., A.D., J.D.G., L.G., S.G.T., D.T.I., B.L., C.A.A.).ORCID 0000-0001-7279-8179
Christian E Anderson *Department of Molecular Physiology and Biophysics, University of Iowa (C.J.C., C.E.A., A.D., J.D.G., L.G., S.G.T., D.T.I., B.L., C.A.A.).ORCID 0000-0002-6112-7828
Alex Dou *Department of Molecular Physiology and Biophysics, University of Iowa (C.J.C., C.E.A., A.D., J.D.G., L.G., S.G.T., D.T.I., B.L., C.A.A.).ORCID 0000-0001-7446-1676
Jason M DierdorffDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa (C.E.A., J.M.D., H.C., J.-Y.Y., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L.).
Jason D GalpinDepartment of Molecular Physiology and Biophysics, University of Iowa (C.J.C., C.E.A., A.D., J.D.G., L.G., S.G.T., D.T.I., B.L., C.A.A.).ORCID 0000-0003-1923-5312
Lionel GissotDepartment of Molecular Physiology and Biophysics, University of Iowa (C.J.C., C.E.A., A.D., J.D.G., L.G., S.G.T., D.T.I., B.L., C.A.A.).
Samantha G ThompsonDepartment of Molecular Physiology and Biophysics, University of Iowa (C.J.C., C.E.A., A.D., J.D.G., L.G., S.G.T., D.T.I., B.L., C.A.A.).ORCID 0000-0002-7205-7343
Hannah ChoiDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa (C.E.A., J.M.D., H.C., J.-Y.Y., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L.).ORCID 0009-0005-5599-5089
Jin-Young YoonDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa (C.E.A., J.M.D., H.C., J.-Y.Y., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L.).ORCID 0000-0002-5707-3636
Daniel T InfieldDepartment of Molecular Physiology and Biophysics, University of Iowa (C.J.C., C.E.A., A.D., J.D.G., L.G., S.G.T., D.T.I., B.L., C.A.A.).ORCID 0009-0004-5295-484X
Jared M McLendonDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa (C.E.A., J.M.D., H.C., J.-Y.Y., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L.).ORCID 0000-0002-1002-5872
Jasmyn M HoegerDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa (C.E.A., J.M.D., H.C., J.-Y.Y., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L.).ORCID 0000-0003-2673-059X
Omar Rabab'hDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa (C.E.A., J.M.D., H.C., J.-Y.Y., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L.).ORCID 0000-0002-6181-3924
Peter BronkCardiovascular Research Center, Rhode Island Hospital and Brown Medical School, Providence (P.B., B.-R.C.).ORCID 0000-0002-9067-2016
Keane LeedsKeane Leeds Analytics, LLC, Iowa City, IA (K.L.).
William J KutschkeDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa (C.E.A., J.M.D., H.C., J.-Y.Y., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L.).ORCID 0000-0002-9358-795X
William J ParadeeGenome Editing Core Facility, Carver College of Medicine, University of Iowa (W.J.P.).
Ryan L BoudreauDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa (C.E.A., J.M.D., H.C., J.-Y.Y., J.M.M., J.M.H., O.R., W.J.K., R.L.B., B.L.).ORCID 0000-0002-9800-5349
Bum-Rak ChoiCardiovascular Research Center, Rhode Island Hospital and Brown Medical School, Providence (P.B., B.-R.C.).ORCID 0000-0001-7319-3219
Barry LondonDepartment of Molecular Physiology and Biophysics, University of Iowa (C.J.C., C.E.A., A.D., J.D.G., L.G., S.G.T., D.T.I., B.L., C.A.A.).ORCID 0000-0003-1506-3947
Christopher A AhernDepartment of Molecular Physiology and Biophysics, University of Iowa (C.J.C., C.E.A., A.D., J.D.G., L.G., S.G.T., D.T.I., B.L., C.A.A.).ORCID 0000-0002-7975-2744

Funding

A Versatile Chemical-Genetic Approach to Determine Bases for Arrhythmogenesis and Sodium ChannelopathiesR01HL163979 · NHLBI · UNIVERSITY OF IOWA · PI Christopher A Ahern, Barry London · 2023 to 2026
$2.6M
Genetic and Molecular Mechanisms of Heart DiseaseR35HL177241 · NHLBI · UNIVERSITY OF IOWA · PI RYAN L BOUDREAU · 2025 to 2026
$2.1M
Regulation and role of the cardiac sodium channel Nav1.5 in heart failureR01HL144717 · NHLBI · UNIVERSITY OF IOWA · PI BOUDREAU, RYAN L · 2019 to 2023
$1.9M
High Resolution Research UltrasoundS10OD038119 · OD · UNIVERSITY OF IOWA · PI WEISS, ROBERT M · 2025 to 2025
$419k
Dissecting the molecular mechanism of the cardiac fight-or-flight response via real-time light-controlled phosphorylation of RadF30HL182065 · NHLBI · UNIVERSITY OF IOWA · PI Alex Kelly Dou · 2025 to 2026
$86k
NHLBI NIH HHS F30 HL182065NHLBI NIH HHS R01 HL144717NHLBI NIH HHS R01 HL163979NHLBI NIH HHS R35 HL177241NIH HHS S10 OD038119
6 · The paper itself

Abstract

backgroundNa

methodsHere, we developed a chemical-genetic mouse model (Na

resultsNa

conclusionsThese results reveal a surprising chamber-specific isoform landscape of cardiac sodium currents, which may underlie the right ventricular predominant phenotype of Brugada syndrome. These data highlight non-Na

Indexed as

Arrhythmias, CardiacHeart VentriclesMyocytes, CardiacNAV1.5 Voltage-Gated Sodium ChannelAction PotentialsAnimalsHeart AtriaMaleMiceMice, Inbred C57BLProtein IsoformsSodium Channel BlockersSulfonamidesVoltage-Gated Sodium Channel BlockersNAV1.5 Voltage-Gated Sodium ChannelProtein IsoformsScn5a protein, mouseSodium Channel BlockersSulfonamidesVoltage-Gated Sodium Channel Blockersarrhythmias, cardiacBrugada syndromeprotein engineeringprotein isoformsvoltage-gated sodium channels

Identifiers

PMID41878815
PMCPMC13045664

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.