Evidence map›Paper›PMID 41878776›Full record

ArticleEuropean journal of cardiovascular nursing2026

The impact of fear of recurrence and progression on mental health after spontaneous coronary artery dissection: the role of illness uncertainty.

Sarah T Clarke, Barbara M Murphy, Michael R Le Grande, Michelle C Rogerson, Jason C Kovacic, Stephanie Hesselson, Siiri E Iismaa, Robert M Graham, Robert Hester, Alun C Jackson

Abstract read
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In one paragraph

Article in European journal of cardiovascular nursing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sarah T ClarkeAustralian Centre for Heart Health, The Royal Melbourne Hospital, PO Box 2137, Melbourne, VIC 3050, Australia.ORCID 0000-0003-1908-1405
Barbara M MurphyAustralian Centre for Heart Health, The Royal Melbourne Hospital, PO Box 2137, Melbourne, VIC 3050, Australia.ORCID 0000-0002-6867-5819
Michael R Le GrandeAustralian Centre for Heart Health, The Royal Melbourne Hospital, PO Box 2137, Melbourne, VIC 3050, Australia.ORCID 0000-0001-5902-6131
Michelle C RogersonAustralian Centre for Heart Health, The Royal Melbourne Hospital, PO Box 2137, Melbourne, VIC 3050, Australia.ORCID 0000-0002-2558-3535
Jason C KovacicVictor Chang Cardiac Research Institute, PO Box 699, Darlinghurst, NSW 2010, Australia.ORCID 0000-0003-4555-769X
Stephanie HesselsonVictor Chang Cardiac Research Institute, PO Box 699, Darlinghurst, NSW 2010, Australia.ORCID 0000-0002-4521-5086
Siiri E IismaaVictor Chang Cardiac Research Institute, PO Box 699, Darlinghurst, NSW 2010, Australia.ORCID 0000-0003-2409-7356
Robert M GrahamVictor Chang Cardiac Research Institute, PO Box 699, Darlinghurst, NSW 2010, Australia.ORCID 0000-0002-1042-2587
Robert HesterMelbourne School of Psychological Sciences, University of Melbourne, Parkville, VIC 3010, Australia.ORCID 0000-0003-0982-8026
Alun C JacksonAustralian Centre for Heart Health, The Royal Melbourne Hospital, PO Box 2137, Melbourne, VIC 3050, Australia.ORCID 0000-0001-9565-1399

Funding

BridgePRS: bridging the gap in polygenic risk scores between ancestries.R01HG012773 · NHGRI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Paul Francis O'Reilly · 2023 to 2026
$2.6M
AgilentAngles Family FoundationAustralian Government Research Training Program ScholarshipBourne FoundationLeducq Foundation 25CVD02National Heart Foundation of AustraliaNHGRI NIH HHS R01 HG012773NSW Health Cardiovascular Senior Scientist APP2010203NSW Health Cardiovascular Senior Scientist RG12159NSW Health Cardiovascular Senior Scientist RG193092Sarah Ford and SCAD Research IncSCAD Research Inc.Snow MedicalUS National Institutes of Health R01HG012773
6 · The paper itself

Abstract

aimsSpontaneous coronary artery dissection (SCAD) is a cause of acute myocardial infarction that is marked by a particularly challenging psychosocial recovery period. Survivors commonly experience fear of recurrent events and uncertainty around their condition. These psychosocial challenges may contribute to anxiety, depression, and cardiac distress. This study investigated the relationship between fear of recurrence and progression (FoRP), uncertainty, and psychological outcomes, specifically whether illness uncertainty moderates the relationship between FoRP and mental health outcomes in SCAD survivors. METHODS AND

resultsParticipants were recruited from the Victor Chang Cardiac Research Institute Arteriopathy and SCAD Cohort (VASC). Two hundred and seventy survivors completed an online questionnaire measuring FoRP, illness uncertainty, anxiety, depression, and cardiac distress. Moderation analyses were undertaken to investigate the relationship between these variables. FoRP directly predicted all three mental health variables. Illness uncertainty moderated this relationship in the case of depression and cardiac distress.

conclusionThe findings indicate specific intervention targets to meet the support needs of survivors. While fear of recurrent events is common following SCAD, managing illness uncertainty may be a means to reduce the impacts of this fear on survivor's mental health.

Indexed as

Coronary Vessel AnomaliesFearMental HealthSurvivorsVascular DiseasesAdultAnxietyCohort StudiesDepressionDisease ProgressionDissection, Blood VesselFemaleHumansMaleMiddle AgedMyocardial InfarctionAnxietyCardiac distressDepressionFear of recurrence and progressionPsychocardiologySCAD

Identifiers

PMID41878776
PMCPMC13549710

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.