ArticleBiological psychiatry global open science2026
Increased Brain-Age Gap in Young Adults With Psychotic Experiences.
Article in Biological psychiatry global open science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Background: Psychotic experiences (hallucinations and delusions: PEs) are linked to structural brain variation, but their relationship to magnetic resonance imaging (MRI)-derived brain age is unclear. We hypothesized that young adults reporting PEs would show an increased brain-age gap (predicted - chronological age) and that this gap would diverge over 10 years. Methods: A multilayer perceptron (2628 training scans; age 6-50 years; mean absolute error = 4.3 years, Results: At the initial time point, individuals with PEs showed a larger brain-age gap than control individuals ( Conclusions: Young adults who report PEs display an older-looking brain in early adulthood, consistent with atypical brain maturation. However, the gap does not clearly widen or contract by age 30. Multimodal, longitudinal cohorts spanning adolescence to midadulthood are needed to map psychosis-related atypical brain maturation.
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