ArticleClinical interventions in aging2026
The Association Between Short-Term Bone Loss and Future Osteoporotic Vertebral Fractures.
Article in Clinical interventions in aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Objective: To investigate the relationship between longitudinal change in Hounsfield Units (HU) value and future osteoporotic vertebral fracture (OVF). Methods: This longitudinal case-control study involved 52 cases with future OVF and 104 age- and sex-matched controls. Each participant underwent two chest computed tomography (CT) scans. The baseline regional (anterior, middle, posterior, superior, inferior) and integral HU value from T4, T7, T10, and L1 vertebrae were measured. The coefficient of variation (CV) indicated heterogeneity in HU. Bone loss was quantified by the annual rate of HU value loss. Conditional logistic regression was employed to evaluate the independent risk factors (baseline CT characteristics and annual HU value loss) for each vertebra in predicting future OVF. Results: The baseline regional and integral HU value of T4, T7, T10 and L1 significantly decreased in OVF patients compared to the controls ( Conclusion: Reduced baseline vertebral HU value and increased annual HU value loss calculated by chest CT may be crucial for predicting OVF, providing valuable guidance for future short-term (approximately 1-3 years) OVF risk evaluation.
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