Evidence map›Paper›PMID 41878591›Full record

ArticleOxford medical case reports2026

Multi-system inflammatory syndrome in a child with Crohn's disease- a diagnostic dilemma.

Barkha Dhanjani, Shivangi Tetarbe, Dhruv Gandhi, Ira Shah

Abstract readCase Reports
In one paragraph

Article in Oxford medical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Barkha DhanjaniDepartment of Pediatric Gastroenterology and Hepatology, Bai Jerbai Wadia Hospital for Children, Acharya Dhonde Marg, Parel, Mumbai, Maharashtra 400012, India.
Shivangi TetarbeDepartment of Pediatric Gastroenterology and Hepatology, Bai Jerbai Wadia Hospital for Children, Acharya Dhonde Marg, Parel, Mumbai, Maharashtra 400012, India.
Dhruv GandhiDepartment of Pediatric Gastroenterology and Hepatology, Bai Jerbai Wadia Hospital for Children, Acharya Dhonde Marg, Parel, Mumbai, Maharashtra 400012, India.ORCID https://orcid.org/0009-0001-7249-7955
Ira ShahDepartment of Pediatric Gastroenterology and Hepatology, Bai Jerbai Wadia Hospital for Children, Acharya Dhonde Marg, Parel, Mumbai, Maharashtra 400012, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Post-covid multisystem inflammatory syndrome in children (MIS-C) can cause life-threatening inflammation in children, particularly in those with underlying conditions like Crohn's disease (CD). The overlap of symptoms between CD flares and MIS-C can create diagnostic and therapeutic challenges, necessitating high-level clinical suspicion and aggressive management when both conditions coexist. We present a 14-year-old boy, with a 3-year history of CD, who presented with diarrhea, abdominal pain, and weight loss. Investigations revealed anemia, thrombocytosis, hypoalbuminemia, and elevated inflammatory markers and fecal calprotectin. He was treated with methylprednisolone and methotrexate. On day 25 of admission, he developed altered sensorium, inability to ambulate, and hypoxia. He was found to have left ventricular dysfunction, non-hepatic hyperammonemia and cerebral sinus thrombosis. Work-up revealed a pro-inflammatory state with elevated serum ferritin, interleukin-6, d-dimers and positive anti-Covid IgG, and led to the diagnosis of MIS-C overlapping with CD flare. He was treated with intravenous immunoglobulin and recovered.

Indexed as

COVID-19Covid antibodiesIBD flareinflammatory bowel diseaseMIS-Cnon-hepatic hyperammonemia

Identifiers

PMID41878591
PMCPMC13007862

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