Evidence map›Paper›PMID 41878570›Full record

ArticleFrontiers in nutrition2026

Dual dimensions of sensitization: age-stratified and disease-associated sIgE profiles in pediatric eczema and urticaria.

Liu Yang, Jiajia Ni, Zhiwei Zhu, Ci Li, Xiang Feng, Nan Chen, Panpan Fang, Junmei Yang, Kaijie Gao

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Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Liu YangZhengzhou Key Laboratory of Children's Infection and Immunity, Department of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China.
Jiajia NiResearch and Development Center, Guangdong Meilikang Bio-Science Ltd, Foshan, Guangdong, China.
Zhiwei ZhuZhengzhou Key Laboratory of Children's Infection and Immunity, Department of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China.
Ci LiZhengzhou Key Laboratory of Children's Infection and Immunity, Department of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China.
Xiang FengZhengzhou Key Laboratory of Children's Infection and Immunity, Department of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China.
Nan ChenZhengzhou Key Laboratory of Children's Infection and Immunity, Department of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China.
Panpan FangZhengzhou Key Laboratory of Children's Infection and Immunity, Department of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China.
Junmei YangZhengzhou Key Laboratory of Children's Infection and Immunity, Department of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China.
Kaijie GaoZhengzhou Key Laboratory of Children's Infection and Immunity, Department of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To characterize sensitization patterns of allergen-specific immunoglobulin E (sIgE) in children with eczema and urticaria, compare differences by disease type and age group, and provide insights for prevention and treatment strategies. Methods: A single-center, retrospective cross-sectional study was performed using serum samples from 4,925 children diagnosed with eczema or urticaria at Henan Children's Hospital between January 2022 and December 2023. Levels of sIgE to inhaled and food allergens were measured using fluorescence immunoassay. Group differences in sensitization rates were compared using chi-square tests, and Spearman correlation analysis was applied to assess relationships between sIgE levels and clinical parameters. Results: The overall positive rate of sIgE was 58.05%, with the positive rate for food allergens (52.93%) significantly higher than that for inhalant allergens (14.05%) ( Conclusion: This study identified distinct age-dependent sIgE sensitization profiles, while disease-associated differences were attenuated after accounting for age and sex. These findings highlight age as a primary dimension for sensitization risk stratification and underscore the clinical value of integrating sIgE monitoring with other biomarkers, such as eosinophils and hemoglobin.

Indexed as

allergenschildreneczemaimmunoglobulin Eurticaria

Identifiers

PMID41878570
PMCPMC13006257

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