ArticleFrontiers in oncology2026
The potential of mitochondrial permeability transition-driven necrosis-related genes in prognostic evaluation of colorectal cancer patients.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Mitochondrial permeability transition-driven necrosis (MPTDN) has been implicated in a variety of diseases, but its relationship with colorectal cancer (CRC) prognosis is unclear. Methods: In this study, TCGA-COAD and TCGA-READ datasets were analyzed to identify differentially expressed genes (DEGs) in CRCs. Differentially expressed MPTDNGRs (DE-MPTDNRGs) were identified by comparing DEGs to MPTDN-related genes (MPTDNRGs). Univariate Cox, Minimum Absolute Contraction and Selection Operator (LASSO) regression and risk scoring analysis divided TCGA-CRC patients into high- and low-risk cohorts. Results: The prognostic genes Conclusion: These findings highlight 5 MPTDN-associated prognostic genes in CRC, providing insights for individualized treatment and prognosis.
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