Evidence map›Paper›PMID 41878399›Full record

ArticleNature reviews. Methods primers2025

Droplet-based bioprinting.

Deepak Gupta, Irem Deniz Derman, Changxue Xu, Yong Huang, Ibrahim T Ozbolat

Abstract read
In one paragraph

Article in Nature reviews. Methods primers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
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  4. Review
  5. Tissue-bioelectronics interfaces.Chemical Society reviews · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Deepak GuptaEngineering Science and Mechanics Department, Penn State University, University Park, PA, USA.
Irem Deniz DermanEngineering Science and Mechanics Department, Penn State University, University Park, PA, USA.ORCID 0000-0001-9824-9071
Changxue XuDepartment of Industrial, Manufacturing, and Systems Engineering, Texas Tech University, Lubbock, TX, USA.
Yong HuangDepartment of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-4691-7370
Ibrahim T OzbolatEngineering Science and Mechanics Department, Penn State University, University Park, PA, USA.ORCID 0000-0001-8328-4528

Funding

Intraoperative bioprinting of composite tissues with zonal stratification for craniomaxillofacial reconstructionR01DE028614 · NIDCR · PENNSYLVANIA STATE UNIVERSITY, THE · PI OZBOLAT, IBRAHIM · 2020 to 2024
$2.8M
3D Printing of Air: An Intangible Ink for Fabrication of Vascularized TissuesR01EB036245 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI Ibrahim Ozbolat, DINO J RAVNIC · 2024 to 2026
$1.7M
Investigating the role of Lef1 in fibroblast lineages to induce skin regeneration and reverse agingR01AR078743 · NIAMS · WASHINGTON STATE UNIVERSITY · PI DRISKELL, RYAN · 2021 to 2025
$1.6M
Developing in situ transcriptomics of a bioprinted follicular skin modelR21AR082668 · NIAMS · JACKSON LABORATORY · PI OH, JULIA, OZBOLAT, IBRAHIM · 2023 to 2023
$439k
NIAMS NIH HHS R01 AR078743NIAMS NIH HHS R21 AR082668NIBIB NIH HHS R01 EB036245NIDCR NIH HHS R01 DE028614
6 · The paper itself

Abstract

Three-dimensional (3D) bioprinting facilitates the automated patterning of biological entities (such as cells and tissue building blocks) with or without scaffolding biomaterials. The technique enables fabrication of highly organized structures that recapitulate the physiological and biological functions of native tissues. Droplet-based bioprinting (DBB) is unique among the existing bioprinting modalities in its ability to handle and manipulate bioprinting at the cellular level, as well as to develop complex 3D constructs in a high-throughput manner. As an evolving bioprinting modality, DBB has greatly advanced our understanding of cell interactions, tissue and organ formation, and human disease. This Primer gives an overview of the methodology of DBB, detailing its various modalities and its associated hardware and software, including the selection of bioinks and substrates, as well as their interactions and compatibility with different DBB sub-modalities. Finally, recent advances and several limitations of DBB are summarized and considerations are discussed for potential improvements to the technology in the future.

Identifiers

PMID41878399
PMCPMC13007925

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.