Evidence map›Paper›PMID 41878326›Full record

ArticleFrontiers in pharmacology2026

Total alkaloids of

Yannan Zheng, Mingyue Lv, Zhichao Xi, Jijia Sun, Mengfan Liu, Trinh Thach Thi Nguyen, Hongmei Zhang, Songlin Li, Min Zheng, Shijie Wan and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yannan Zheng *School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Mingyue Lv *School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zhichao XiSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jijia SunCollege of Artificial Intelligence, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Mengfan LiuSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Trinh Thach Thi NguyenSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Hongmei ZhangSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Songlin LiDepartment of Metabolomics, Jiangsu Province Academy of Traditional Chinese Medicine and Jiangsu Branch of China Academy of Chinese Medical Sciences, Nanjing, China.
Min ZhengSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Shijie WanDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, United States.
Hua LiFujian Key Laboratory of Chinese Materia Medica, Institute of Structural Pharmacology & TCM Chemical Biology, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Man YuanSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Hongxi XuSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Materials and Methods: An ovalbumin (OVA)-induced asthma mouse model was used to detect TAL's effects on airway hyperresponsiveness, lung inflammation, and Th2 cytokines. For Results: TAL significantly alleviated allergic symptoms, reduced airway hyperresponsiveness, and decreased lung mast cell infiltration. Transcriptomic analysis revealed that hypoxia-related pathways, particularly HIF-1α, were downregulated following TAL intervention. TAL suppressed HIF-1α protein expression, reduced mast cell degranulation, and Th2 cytokines both Conclusion: TAL alleviates allergic asthma by suppressing HIF-1α-mediated mast cell activation and associated inflammation responses, supporting its potential application in inflammatory airway diseases.

Indexed as

allergic asthmahypoxiaLeonurus japonicus houtt.mast celltotal alkaloids

Identifiers

PMID41878326
PMCPMC13006691

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.