Evidence map›Paper›PMID 41878316›Full record

ArticleAmerican journal of stem cells2026

A bioactive composite of freeze-dried stem cells, porous microcarriers, and fibrinogen-thrombin gel for dental pulp tissue engineering.

Mariam Z Kakabadze, Tamta Jikia, Teona Paresishvili, Lia Karalashvili, David Chakhunashvili, Merab Janelidze, Zurab Kakabadze

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Article in American journal of stem cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mariam Z KakabadzeDepartment of Clinical and Experimental Morphology, Tbilisi State University Tbilisi, Georgia.
Tamta JikiaDepartment of Clinical Anatomy, Tbilisi State Medical University Tbilisi, Georgia.
Teona ParesishviliDepartment of Clinical Anatomy, Tbilisi State Medical University Tbilisi, Georgia.
Lia KaralashviliDepartment of Clinical Anatomy, Tbilisi State Medical University Tbilisi, Georgia.
David ChakhunashviliDepartment of Clinical Anatomy, Tbilisi State Medical University Tbilisi, Georgia.
Merab JanelidzeDepartment of Surgery, Georgian National University Tbilisi, Georgia.
Zurab KakabadzeDepartment of Clinical Anatomy, Tbilisi State Medical University Tbilisi, Georgia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to develop a novel biocompatible composite for the regeneration of damaged dental pulp tissue. MATERIALS AND

methodsTo create the composite, porous microcarriers were loaded with freeze-dried bone marrow stem cells and embedded in a fibrinogen-thrombin gel. The regenerative potential of the composite was evaluated in both ectopic and orthotopic animal models of dental pulp injury.

resultsThe composite stimulated the migration and proliferation of host pulp cells via growth factors and cytokines secreted by freeze-dried bone marrow stem cells. Furthermore, the microcarrier-based scaffold created a three-dimensional microenvironment that preserved the paracrine activity of stem cells, promoting the effective regeneration of damaged or partially amputated dental pulp.

conclusionThis bioactive composite demonstrates significant potential for regenerative endodontics, facilitating the restoration of dental pulp. Further studies are needed to elucidate the specific role of paracrine factors from freeze-dried stem cells in improving pulp tissue regeneration.

Indexed as

decellularization of a toothfibrinogen-thrombin gelFreeze-dried bone marrow stem cellspulp-dentin complexregenerative endodonticsthree-dimensional microcarrierstooth scaffold

Identifiers

PMID41878316
PMCPMC13006739

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.