ArticleInternational journal of chronic obstructive pulmonary disease2026
Association Between Subsegmental Dosing Accuracy and Outcomes of Bronchoscopic Thermal Vapor Ablation: An Exploratory Retrospective Study in Severe Heterogeneous Emphysema.
Article in International journal of chronic obstructive pulmonary disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Bronchoscopic thermal vapor ablation (BTVA) is a minimally invasive treatment for severe emphysema. However, the treatment doses are typically generated at the segmental level. In specific cases, treatment needs to be conducted at the subsegmental level, and the proportion can only be roughly allocated based on CT image review, potentially leading to dose mismatch. This retrospective exploratory study investigated the relationship between subsegmental dose accuracy (theoretical-to-actual matching) and clinical outcomes following BTVA. Methods: Patients who underwent BTVA at the Shanghai Chest Hospital between 2023 and 2024 were analyzed. Subsegmental theoretical doses (BroncQCT software) were compared to previously administered actual treatment doses. Dose matching was defined as: 1) segmental treatments were presumed matched (uniform vapor assumption), 2) subsegmental treatments required ≤10% deviation between actual and theoretical dose ratios (|Actual ratio - Theoretical ratio| × 100%). Patients with >10% deviation or BroncQCT-identified nontarget subsegments were unmatched. Clinical parameters at 1, 3, 6, and 12 months after single treatment were compared. Results: Among 21 patients (15 matched, 6 unmatched), the mean changes in FEV Conclusion: This exploratory study found that subsegmental dose matching was associated with greater FEV
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