Evidence map›Paper›PMID 41878284›Full record

ArticleERJ open research2026

Diffusing capacity of the lung for carbon monoxide, transfer coefficient of the lung for carbon monoxide and forced vital capacity/diffusing capacity of the lung for carbon monoxide in suspected systemic sclerosis-associated pulmonary hypertension: insights from the ASPIRE registry.

Howard Smith, A A Roger Thompson, Mohammed Akil, Samer Alabed, Catherine Billings, Athanasios Charalampopoulos, Krit Dwivedi, Charlie A Elliot, Abdul Hameed, Ashraful Haque and 11 more

Abstract read
In one paragraph

Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Howard SmithSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK.
A A Roger ThompsonSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK.ORCID https://orcid.org/0000-0002-0717-4551
Mohammed AkilDepartment of Rheumatology, Royal Hallamshire Hospital, Sheffield, UK.
Samer AlabedDepartment of Radiology, Royal Hallamshire Hospital, Sheffield, UK.ORCID https://orcid.org/0000-0002-9960-7587
Catherine BillingsSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK.
Athanasios CharalampopoulosSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK.
Krit DwivediDepartment of Radiology, Royal Hallamshire Hospital, Sheffield, UK.ORCID https://orcid.org/0000-0003-4949-4550
Charlie A ElliotSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK.
Abdul HameedSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK.ORCID https://orcid.org/0000-0002-2128-2081
Ashraful HaqueDepartment of Rheumatology, Royal Hallamshire Hospital, Sheffield, UK.
Neil HamiltonSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK.
Catherine HillDepartment of Radiology, Royal Hallamshire Hospital, Sheffield, UK.
Judith HurdmanSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK.
Rachael KildingDepartment of Rheumatology, Royal Hallamshire Hospital, Sheffield, UK.
Kar-Ping KuetDepartment of Rheumatology, Royal Hallamshire Hospital, Sheffield, UK.
Smitha RajaramDepartment of Radiology, Royal Hallamshire Hospital, Sheffield, UK.
Alexander M K RothmanSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK.
Ian SmithSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK.
Andrew J SwiftDepartment of Radiology, Royal Hallamshire Hospital, Sheffield, UK.
David G KielySheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK.ORCID https://orcid.org/0000-0003-0184-6502
Robin CondliffeSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK.ORCID https://orcid.org/0000-0002-3492-4143

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: There are limited data comparing parameters reflecting gas transfer used to assess the likelihood of pulmonary hypertension (PH) in patients with systemic sclerosis (SSc) and regarding the impact of transitioning to Global Lung Initiative (GLI)-predicted values. Methods: 632 patients with suspected SSc-associated PH were identified from the ASPIRE registry. Spirometry and computed tomography reports were reviewed to identify significant lung disease. Receiver operating characteristic curve analysis and correlations of the three markers of gas transfer with pulmonary arterial pressure were performed. Results: Correlations of GLI-derived values with mean pulmonary arterial pressure were diffusing capacity of the lung for carbon monoxide ( Conclusion:

Identifiers

PMID41878284
PMCPMC13006901

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.