Evidence map›Paper›PMID 41878282›Full record

ArticleERJ open research2026

Integrative genomics reveal genetic links of chronic cough with risk factors and brain regional volumes.

Zikai Lin, Junfeng Huang, Linzhi He, Shuojia Xie, Gongping Shu, Gengjia Chen, Weitong Lin, Xiaowen Zhong, Shiyue Li, Kian Fan Chung and 1 more

Abstract read
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Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

11 authors.

Zikai LinState Key Laboratory of Respiratory Disease, Joint International Research Laboratory of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China.ORCID https://orcid.org/0000-0002-0247-8628
Junfeng HuangState Key Laboratory of Respiratory Disease, Joint International Research Laboratory of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China.
Linzhi HeState Key Laboratory of Respiratory Disease, Joint International Research Laboratory of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China.
Shuojia XieState Key Laboratory of Respiratory Disease, Joint International Research Laboratory of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China.
Gongping ShuState Key Laboratory of Respiratory Disease, Joint International Research Laboratory of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China.
Gengjia ChenState Key Laboratory of Respiratory Disease, Joint International Research Laboratory of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China.
Weitong LinState Key Laboratory of Respiratory Disease, Joint International Research Laboratory of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China.
Xiaowen ZhongState Key Laboratory of Respiratory Disease, Joint International Research Laboratory of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China.
Shiyue LiState Key Laboratory of Respiratory Disease, Joint International Research Laboratory of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China.
Kian Fan ChungNational Heart and Lung Institute, Imperial College London, and Royal Brompton and Harefield Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK.ORCID https://orcid.org/0000-0001-7101-1426
Ruchong ChenState Key Laboratory of Respiratory Disease, Joint International Research Laboratory of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China.ORCID https://orcid.org/0000-0001-5376-8230

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Chronic cough is a common condition, particularly among women in their sixties, and is associated with a high disease burden and reduced quality of life. Limited understanding of its risk factors and genetic associations represents a barrier to its effective management. Methods: We used genome-wide association study datasets for respiratory and other diseases, as well as behavioural phenotypes from the UK Biobank, FinnGen, Global Biobank Meta-analysis Initiative and Psychiatric Genomics Consortium. We identified pleiotropic genetic associations with chronic cough using linkage disequilibrium score regression, pleiotropy analysis and Bayesian colocalisation analysis. We conducted Mendelian randomisation analysis to determine the association between brain regional volumes and chronic cough risk. Results: We identified 19 significant genetic correlations between chronic cough and various risk factors and associations. Among 74 pleiotropic genomic loci identified, the 4p14 locus had the strongest effect on cough-associated asthma, with RFC1 linked to cerebellar ataxia, neuropathy and vestibular areflexia syndrome. Gene enrichment analyses highlighted that the central nervous system and ion channel activity play roles in the pathogenesis of cough. A reduction in the volume of isthmus cingulate, thalamus proper and pallidum was associated with an increased risk of chronic cough. In ageing-associated cough, the direct effect of ageing on chronic cough showed an increased odds ratio of 1.044, while a reduction in left pallidum volume was associated with a decreased risk, with an odds ratio of 0.902. Conclusions: This genetic basis of chronic cough risk and its associations highlights both structural and functional genetic overlap, confirming the impact of reductions in brain regional volumes on chronic cough as a result of ageing.

Identifiers

PMID41878282
PMCPMC13006902

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