ArticleNeuropsychiatric disease and treatment2026
Psychosocial and Biological Factors Associated with Non-Suicidal Self-Injury in Chinese Child and Adolescent Inpatients with Major Depressive Disorder.
Article in Neuropsychiatric disease and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Object: This study assessed the prevalence and associated psychosocial and biological factors of non-suicidal self-injury (NSSI) in Chinese child and adolescent inpatients diagnosed with major depressive disorder (MDD) by DSM-5 criteria. Methods: This cross-sectional study included 177 inpatients aged 10-16 years. Participants were assessed using the Childhood Trauma Questionnaire (CTQ), Hamilton Depression Scale (HAMD-24), Hamilton Anxiety Scale (HAMA), Shame Scale for Middle School Students (SS), and Mobile Phone Addiction Index (MPAI). Fasting blood levels of cortisol, thyroid hormones, and inflammatory markers were measured. Group comparisons (NSSI vs non-NSSI) used t-tests and chi-square tests, followed by binary logistic regression to identify independent associated factors of NSSI. Results: NSSI prevalence was 69.49%, with a higher proportion of females in the NSSI group. Compared to the non-NSSI patients, the NSSI group exhibited significantly higher scores on the HAMD-24, HAMA, shame, and MPAI scales, as well as higher cortisol and lower free triiodothyronine (FT3) levels. No significant differences were found in other biomarkers (Hypersensitive C-reactive protein, FT4, T3, T4, TSH, Adrenocorticotropic hormone). Regression analysis identified emotional neglect (OR = 1.223), depression severity (OR = 1.197), anxiety (OR = 1.186), shame (OR = 1.046), and cortisol (OR = 1.081) as significant factors associated with NSSI. Smartphone addiction and thyroid function-related indicators showed no significant association in the regression model. Conclusion: NSSI is highly prevalent among child and adolescent inpatients with MDD and is associated with emotional neglect, depressive and anxiety symptoms, shame-proneness, and dysregulated cortisol levels. Smartphone addiction and other biological markers (Hypersensitive C-reactive protein, FT4, T3, T4, TSH, and Adrenocorticotropic hormone) showed no independent association with NSSI in the final model. These findings highlight the importance of integrated management of psychological and biological indicators in high-risk children and adolescents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.