ArticleFrontiers in neurology
Distinct phenotype of isolated dizziness stroke: association with cerebellar infarctions and elevated LDL-C.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Distinguishing ischemic stroke in patients presenting with isolated dizziness or vertigo (IDV) from more benign causes remains a significant clinical challenge. Current understanding of the specific clinical and imaging characteristics that differentiate IDV strokes from strokes with non-isolated symptoms (NIDV) is incomplete. Objective: This study aimed to systematically compare the clinical characteristics, with a specific focus on infarction topography and lipid profiles, between patients with acute cerebral infarction presenting with IDV and those with NIDV. Methods: In this retrospective cohort study, we analyzed 136 patients with Magnetic Resonance Imaging (MRI)-confirmed acute cerebral infarction who presented with dizziness/vertigo. Patients were classified into IDV ( Results: Univariate analysis revealed that the primary differences between groups lay in infarction topography and lipid profiles. Specifically, infarctions in the cerebellar hemisphere (47.2% vs. 25.3%; Conclusion: In patients with confirmed acute cerebral infarction, those presenting with isolated dizziness/vertigo (IDV) represent a distinct phenotype characterized by a predisposition to cerebellar infarctions and a higher atherogenic lipid burden, specifically elevated LDL-C. These findings challenge the notion of a benign underlying vasculopathy in IDV stroke and underscore the necessity of comprehensive vascular assessment, including lipid profiling, in this patient population.
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