ArticleACG case reports journal2026
Rare Rectal Involvement of Metastatic Appendiceal Adenocarcinoma Mimicking Primary Rectal Cancer.
Article in ACG case reports journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Primary appendiceal adenocarcinoma is a rare gastrointestinal malignancy that typically metastasizes to the peritoneum. Metastatic rectal involvement is exceptionally rare. We describe the case of a previously healthy 44-year-old man diagnosed with metastatic appendiceal adenocarcinoma. Sixteen months after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, he developed new-onset constipation and tenesmus. Subsequent colonoscopy revealed a large ulcerated rectal mass, consistent with possible metastatic poorly differentiated adenocarcinoma based on histology, immunoprofiling (CK20-positive, CDX2-positive, CK7-negative), and clinical history. To our knowledge, this represents the second possible documented case of rectal metastasis from appendiceal cancer in the literature, and the first to propose a potential mechanism for its spread.
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