Evidence map›Paper›PMID 41878125›Full record

ArticleInternational journal of nanomedicine2026

CD44 Receptor-Mediated Delivery of ROS/pH Dual-Sensitive Nanoparticles Based on Poly(Ethylene Glycol)-

Tae Hyeon Kim, Woong Kim, Won-Jin Kim, Ji-Sun Park, Se-Yoon Park, Young-I L Jeong, Ho-Joong Kim, Seok-Jun Kim

Abstract read
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In one paragraph

Article in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tae Hyeon Kim *Division of Animal Science, Gyeongsang National University, Jinju, 52828, Korea.
Woong Kim *Institute of Well-Aging Medicare & Chosun University G-LAMP Project Group, Chosun University, Gwangju, 61452, Korea.
Won-Jin KimInstitute of Well-Aging Medicare & Chosun University G-LAMP Project Group, Chosun University, Gwangju, 61452, Korea.
Ji-Sun ParkInterdisciplinary Program of Perfume and Cosmetic, Chonnam National University, Gwangju, 61186, Korea.
Se-Yoon ParkDepartment of Chemistry, Chosun University, Gwangju, 61452, Korea.
Young-I L JeongInstitute of Well-Aging Medicare & Chosun University G-LAMP Project Group, Chosun University, Gwangju, 61452, Korea.ORCID 0000-0002-9832-4331
Ho-Joong KimDepartment of Chemistry, Chosun University, Gwangju, 61452, Korea.
Seok-Jun KimInstitute of Well-Aging Medicare & Chosun University G-LAMP Project Group, Chosun University, Gwangju, 61452, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study aimed to develop and evaluate acidic pH- and reactive oxygen species (ROS)-sensitive triblock copolymer nanoparticles, composed of poly(ethylene glycol) (PEG), poly(doxorubicin) (DOX), and hyaluronic acid (HA), for targeted anticancer drug delivery. Methods: PEG-PolyDOX (PPD) diblock copolymer and PEG-PolyDOX-HA (PPDHA) triblock copolymer nanoparticles were synthesized and characterized for their responsiveness to tumor microenvironmental conditions, including acidic pH and oxidative stress. In vitro assays were conducted using MDA-MB-231 breast cancer cells to assess cytotoxicity, apoptosis, necrosis, and CD44 receptor-mediated uptake. In vivo biodistribution and therapeutic efficacy were evaluated in an MDA-MB-231 xenograft mouse model compared with DOX and PPD nanoparticles. Results: PPDHA nanoparticles exhibited morphological and size distribution changes, along with accelerated DOX release, under acidic pH and H Conclusion: PPDHA nanoparticles demonstrated tumor-specific delivery and superior anticancer efficacy in vitro and in vivo. These findings suggest that PPDHA nanoparticles are promising candidates for targeted anticancer drug delivery.

Indexed as

DoxorubicinHyaluronan ReceptorsHyaluronic AcidNanoparticlesPolyethylene GlycolsReactive Oxygen SpeciesAnimalsAntineoplastic AgentsApoptosisBreast NeoplasmsCell Line, TumorCell SurvivalFemaleHumansHydrogen-Ion ConcentrationMDA-MB-231 CellsAntineoplastic AgentsDoxorubicinHyaluronan ReceptorsHyaluronic AcidPolyethylene GlycolsReactive Oxygen Speciesacidic pHblock copolymerCD44 receptordoxorubicinoxidative stress

Identifiers

PMID41878125
PMCPMC13006383

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.