ReviewInternational journal of nanomedicine2026
Janus Membranes as Multifunctional Nanostructures for Bone Defect Repair: Advances, Challenges, and Clinical Translation.
Review in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Advanced Nanomaterials for Chronic Wounds: M.O.I.S.T. Concept-Driven Design Strategy.Advanced healthcare materials · 2026Review
- Application of Temporally Controlled Release Systems in Periodontal Tissue Regeneration: From Material Design to Therapeutic Strategies.Pharmaceutics · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone defect repair, particularly for critically sized defects, remains a formidable clinical challenge owing to the limitations of conventional bone grafts and single-functional scaffolds. Janus membranes, with their asymmetric structure and capacity for multi-functional integration, offer an innovative "all-in-one" solution for bone tissue engineering. This review systematically outlines recent advancements in Janus membranes for bone repair, focusing on three core aspects: nanofabrication strategies for achieving asymmetric properties (eg wettability, charge, and porosity), multi-functional designs that mimic the natural periosteum for guided bone regeneration, antibacterial activity, soft-tissue integration, and haemostasis, and clinical translation potential along with future perspectives. This review summarises the progress in the use of Janus membranes as multi-functional nanostructures for bone regeneration. It systematically introduces the manufacturing techniques for Janus membranes, such as the layer-by-layer method and ion-modification approaches. Furthermore, it focuses on the dual-functional and multi-functional designs of Janus membranes and their integration with nanotechnology. In addition, we delve into the current challenges (eg complexity in manufacturing processes and limited research on material mechanical properties) and propose potential solutions, such as intelligent manufacturing (eg 3D printing) and dynamic response systems. This review provides a comprehensive reference for the field and promotes the clinical translation of Janus membranes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.