Evidence map›Paper›PMID 41877910›Full record

ArticleInfection and drug resistance2026

Pathogenic Characteristics and Molecular Epidemiological Analysis of

Zihan Zhao, Xueping Cao, Jinhui Li, Kaiying Wang, Peng Li, Wei Zhang, Jia Liu, Tao Sun, Xiaoli Yang, Yufei Wang and 2 more

Abstract read
In one paragraph

Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zihan Zhao *College of Veterinary Medicine, Anhui Agricultural University, Anhui, 230036, People's Republic of China.
Xueping Cao *Department of Clinical Laboratory, The Third MedicalCenter, PLA General Hospital, Beijing, 100039, People's Republic of China.
Jinhui Li *Department of Biosecurity, The Chinese PLA Center for Disease Control and Prevention, Beijing, 100071, People's Republic of China.
Kaiying Wang *Department of Biosecurity, The Chinese PLA Center for Disease Control and Prevention, Beijing, 100071, People's Republic of China.
Peng LiDepartment of Biosecurity, The Chinese PLA Center for Disease Control and Prevention, Beijing, 100071, People's Republic of China.
Wei ZhangDepartment of Clinical Laboratory, The Third MedicalCenter, PLA General Hospital, Beijing, 100039, People's Republic of China.
Jia LiuDepartment of Clinical Laboratory, The Third MedicalCenter, PLA General Hospital, Beijing, 100039, People's Republic of China.
Tao SunDepartment of Clinical Laboratory, The Third MedicalCenter, PLA General Hospital, Beijing, 100039, People's Republic of China.
Xiaoli YangDepartment of Clinical Laboratory, The Third MedicalCenter, PLA General Hospital, Beijing, 100039, People's Republic of China.
Yufei WangDepartment of Clinical Laboratory, The Third MedicalCenter, PLA General Hospital, Beijing, 100039, People's Republic of China.
Mengling PengCollege of Veterinary Medicine, Anhui Agricultural University, Anhui, 230036, People's Republic of China.
Peihan LiDepartment of Biosecurity, The Chinese PLA Center for Disease Control and Prevention, Beijing, 100071, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: In this study, we isolated KP strains from UTI patients and performed antimicrobial susceptibility testing, whole-genome sequencing (WGS), and comprehensive genomic analyses to delineate their molecular characteristics. Results: Multilocus sequence typing (MLST) identified 41 sequence types (STs), with ST11 being the most prevalent. Phylogenetic analysis revealed that most local strains clustered closely with the globally disseminated KP clonal group 258 (CG258), suggesting a potential origin from this epidemic lineage. All isolates carried virulence and antibiotic resistance genes, with ST11 strains exhibiting the highest resistance gene burden, classifying them as multidrug-resistant (MDR). We further characterized the plasmid pNDM-MAR and identified biosynthetic gene clusters (BGCs) for redox-cofactors, azole-containing RiPPs, terpene precursors, NRP-metallophores, type I polyketide synthases (T1PKS), RiPP-like compounds, and non-ribosomal peptide synthetase-independent siderophores (NI-siderophores). Discussion: These findings underscore the convergence of hypervirulence and multidrug resistance in KP, highlighting the need for continuous genomic surveillance to inform infection control strategies and antimicrobial stewardship.

Indexed as

epidemiological characteristicsKlebsiella pneumoniaephylogenetic analysisplasmidsecondary metabolite genesurinary tract infection

Identifiers

PMID41877910
PMCPMC13007690

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.