Evidence map›Paper›PMID 41877906›Full record

ArticleInfection and drug resistance2026

A Diagnostic Accuracy Study of Combined OMP22-PCR and SAT for Brucellosis in Xinjiang, China.

Minghui Yun, Jing Chen, Yang Zhou, Chao Wei, Kaiting Zhang, Chanjuan Zhang, Chuanlong Zhu, Songsong Xie

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Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Minghui Yun *NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases(Co-Construction), The First Affiliated Hospital of Shihezi University, The Clinical Research Center for Infectious Diseases of Xinjiang Production and Construction Corps, Shihezi, 832099, People's Republic of China.
Jing Chen *Nanjing Medical University, Nanjing, 210000, People's Republic of China.
Yang Zhou *NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases(Co-Construction), The First Affiliated Hospital of Shihezi University, The Clinical Research Center for Infectious Diseases of Xinjiang Production and Construction Corps, Shihezi, 832099, People's Republic of China.
Chao WeiNHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases(Co-Construction), The First Affiliated Hospital of Shihezi University, The Clinical Research Center for Infectious Diseases of Xinjiang Production and Construction Corps, Shihezi, 832099, People's Republic of China.
Kaiting ZhangNHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases(Co-Construction), The First Affiliated Hospital of Shihezi University, The Clinical Research Center for Infectious Diseases of Xinjiang Production and Construction Corps, Shihezi, 832099, People's Republic of China.
Chanjuan ZhangNHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases(Co-Construction), The First Affiliated Hospital of Shihezi University, The Clinical Research Center for Infectious Diseases of Xinjiang Production and Construction Corps, Shihezi, 832099, People's Republic of China.
Chuanlong ZhuDepartment of Infectious Diseases, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210000, People's Republic of China.ORCID 0000-0002-0657-828X
Songsong XieNHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases(Co-Construction), The First Affiliated Hospital of Shihezi University, The Clinical Research Center for Infectious Diseases of Xinjiang Production and Construction Corps, Shihezi, 832099, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The standard tube agglutination test (SAT) is a cornerstone for brucellosis diagnosis but has inherent limitations, including false negatives in early and chronic infections and false positives due to cross-reactivity. To overcome these drawbacks, molecular detection targeting the highly conserved Methods: From January 2023 to May 2024, serum samples from 62 culture-confirmed brucellosis patients and 25 controls were analyzed using OMP22-PCR and SAT. Diagnostic performance was compared, discordant results were analyzed, and OMP22 detection was extended to 20 clinical isolates, 20 urine samples, and 2 cerebrospinal fluid (CSF) samples. Results: OMP22-PCR demonstrated a sensitivity of 93.5% and specificity of 92.0%, which was comparable to SAT (96.8% and 88.0%, respectively; both Conclusion: The combination of OMP22-PCR and SAT effectively compensates for the limitations of each method alone, significantly enhancing diagnostic accuracy. The strong performance of OMP22-PCR in non-blood samples further underscores its value as a complementary tool, thereby supporting the development of more comprehensive diagnostic strategies for brucellosis.

Indexed as

brucellosisdiagnostic efficacyOMP22PCRstandard tube agglutination test

Identifiers

PMID41877906
PMCPMC13007675

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