ReviewJournal of inflammation research2026
Exosomes Regulate Liver Diseases Through the TGF-β1/Smads Signaling Pathway and the Intervention of Traditional Chinese Medicine: A Narrative Review.
Review in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Pharmacological Effects and Proposed Mechanisms ofLife (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liver disease is a common chronic illness with increasing incidence and mortality. Exosomes are small membrane vesicles (30-200 nm) containing complex RNAs and proteins that serve as mediators of intercellular communication. The role of exosomes in liver disease is complex and sometimes contradictory. In certain situations, they may suppress liver disease, whereas in others, they promote its progression. This duality raises important questions regarding the overall impact of these drugs on the treatment of liver disease. The Transforming Growth Factor-beta1 (TGF-β1)/Smads signaling pathway plays a significant role in the occurrence and development of liver diseases, and exosomes mediate liver disease by regulating the TGF-β1/Smads signaling pathway. Research has shown that Traditional Chinese Medicine (TCM) can exert liver-protective effects by influencing exosomes to modulate the TGF-β1/Smads signaling pathway. Using keywords such as "exosomes", "TGF-β1/Smads signaling pathway", "liver fibrosis", "hepatocellular carcinoma", "liver diseases", and "traditional Chinese medicine", this article reviews the literature from databases, including CNKI, PubMed, and SCOPUS. It summarizes how exosome-mediated regulation of the TGF-β1/Smads signaling pathway affects the development of liver diseases and compiles relevant studies on the anti-liver disease effects of TCM through exosomal modulation of this pathway.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.