SynthesisFrontiers in medicine2026
Maternal hyperuricemia and adverse maternal-fetal outcomes: a systematic review and meta-analysis of observational studies.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
12 authors.
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Abstract
Background: Maternal serum uric acid (SUA) has been suggested as a biomarker for adverse pregnancy outcomes, but findings remain inconsistent. This systematic review and meta-analysis evaluated the association between elevated maternal SUA levels and key obstetric and neonatal outcomes. Methods: A comprehensive search of PubMed, Scopus, Web of Science, and the Cochrane Library was conducted through December 2024. Observational studies reporting associations between high maternal SUA levels and pregnancy outcomes were included. Data were pooled using a random-effects model as odds ratios (ORs). Heterogeneity was assessed using the Results: A total of 30 studies met the inclusion criteria. Elevated maternal SUA levels were significantly associated with increased odds of preterm birth (PTB; OR = 2.05, 95% CI: 1.55-2.72, Conclusion: This meta-analysis shows an association between elevated maternal SUA levels and adverse maternal and neonatal outcomes. However, the evidence is derived from heterogeneous observational studies and does not support causal inference or routine SUA-based screening in clinical practice. Maternal SUA may be a promising biomarker, but large, well-designed prospective studies are needed to validate these findings and clarify its incremental predictive value. Systematic review registration: CRD420251038421, https://www.crd.york.ac.uk/PROSPERO/view/CRD420251038421.
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