ArticlePediatric gastroenterology, hepatology & nutrition2026
Correlation Between Non-Invasive Biomarkers and Histological Healing in Children with Celiac Disease: Role of Cytokines, Intestinal Fatty Acid-Binding Protein, and Tissue Transglutaminase Antibodies.
Article in Pediatric gastroenterology, hepatology & nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Data on treatment response in children with celiac disease (CeD), particularly with respect to changes in tissue transglutaminase IgA antibodies (tTGA-IgA), cytokines, intestinal fatty acid-binding protein (I-FABP), and quantitative histology, remain limited. To evaluate the utility of non-invasive parameters (NIPs), including I-FABP, tTGA-IgA, and cytokines, as potential markers of mucosal recovery in pediatric CeD. Methods: This single-center, prospective, observational follow-up study included children with newly diagnosed CeD. Blood and duodenal biopsy samples were obtained at baseline and after 1 year of follow-up. Results: Seventy-nine children who underwent follow-up biopsy at 1 year were analyzed. Significant improvements were observed in anthropometric measures, histological parameters, tTGA-IgA levels, cytokine profiles (tumor necrosis factor-alpha [TNF-α], interferon-gamma [IFN-γ], interleukin [IL]-15, IL-6, and IL-10), and I-FABP levels. tTGA-IgA showed strong correlations with histological indices, including intraepithelial lymphocyte (IEL) count (r=0.554, Conclusion: Among the NIPs evaluated, tTGA-IgA showed the strongest correlation with mucosal recovery at 1 year. TNF-α, IL-15, and IFN-γ demonstrated weaker but significant correlations and may have the potential as adjunctive NIP of mucosal healing in pediatric CeD.
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