Evidence map›Paper›PMID 41877710›Full record

ArticlePediatric gastroenterology, hepatology & nutrition2026

Diagnosing Congenital Sucrase-Isomaltase Deficiency in Children: An Algorithm Using Combined Breath Testing.

Brett J Hoskins, Jeanette Freeman, Shaija Kutty, Steven D Miller, Jennifer Smith, Ann O Scheimann, Wikrom Karnsakul

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric gastroenterology, hepatology & nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brett J HoskinsDivision of Pediatric Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Riley Hospital for Children at IU Health, Indianapolis, IN, USA.ORCID https://orcid.org/0000-0003-3048-5662
Jeanette FreemanDepartment of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Shaija KuttyDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Steven D MillerDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jennifer SmithDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ann O ScheimannDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0001-5615-7662
Wikrom KarnsakulDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0001-7288-5459

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Disaccharidase deficiencies, including sucrase-isomaltase deficiency, can cause chronic gastrointestinal symptoms in children. While duodenal biopsies remain the diagnostic gold standard, results may be confounded by specimen handling variability or secondary mucosal injury. The noninvasive Methods: We conducted a retrospective review of 25 pediatric patients with disaccharidase deficiencies on duodenal biopsy and normal villous architecture. Patients underwent Results: Of 21 patients with low sucrase activities who completed Conclusion: Biopsy-based diagnosis may overestimate true CSID due to secondary causes or technical artifacts. Combined use of the

Indexed as

13C sucrose breath testBreath testCongenital sucrase-isomaltase deficiencyDisaccharidasesNoninvasive diagnosticsSmall intestinal bacterial overgrowth

Identifiers

PMID41877710
PMCPMC13006571

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.