Evidence map›Paper›PMID 41877704›Full record

ArticleCyborg and bionic systems (Washington, D.C.)2026

Ferrocene-Modified Nanoscale Covalent Organic Frameworks for Ferroptosis-Based Sonodynamic Therapy Inhibit Breast Cancer and Its Bone Metastasis.

Ming Wu, Yiqing Zeng, JianGang Chen, Zhen Yang, Siyuan Song, Rongkai Yan, Taofik Al Hassan, Yan Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cyborg and bionic systems (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ming WuDepartment of Orthopaedics, Gongli Hospital of Pudong New Area, Shanghai 200135, China.
Yiqing ZengDepartment of Ultrasound, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
JianGang ChenPostgraduate Training Base at Shanghai Gongli Hospital, Ningxia Medical University, Shanghai 750004, China.
Zhen YangDepartment of Orthopaedics, Gongli Hospital of Pudong New Area, Shanghai 200135, China.
Siyuan SongBaylor College of Medicine, Houston, TX 77030, USA.
Rongkai YanDepartment of Radiology, Ohio State University, Columbus, OH 43210, USA.
Taofik Al HassanDepartment of Radiology, Ohio State University, Columbus, OH 43210, USA.
Yan ZhangDepartment of Orthopaedics, Gongli Hospital of Pudong New Area, Shanghai 200135, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer continues to be a marked risk to women's health worldwide. In particular, bone metastasis stands as one of the leading causes of death among breast cancer patients. In recent years, therapies that reprogram the tumor's immunosuppressive microenvironment have emerged as promising antimetastatic strategies. In this study, we developed a sonodynamic nanoplatform that simultaneously eradicates primary breast tumors via ferroptosis and apoptosis and blocks their spread to bone tissues. Ferrocene-grafted nanoconfined covalent organic frameworks (mCOFs) were synthesized by condensing aminoferrocene with micrometer-sized COFs, yielding a multifunctional agent capable of amplifying reactive oxygen species (ROS) production. Following ultrasound treatment, the mCOFs generated abundant ROS, while the ferrocene moieties catalyzed the Fenton-like conversion of endogenous H

Identifiers

PMID41877704
PMCPMC13006732

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.