Evidence map›Paper›PMID 41877626›Full record

ArticleActa biochimica et biophysica Sinica2026

Atractylenolide I mitigates Alzheimer's disease pathology in ApoE

Xun Zhou, Rui Wang, Jingsi Yan, Xiaolang Wu, Dongsheng Yuan, Qi Wang, Huilin Li, Wei Zhao

Abstract read
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xun ZhouDepartment of Endocrinology, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, China.
Rui WangHospital of Fengnan District Tangshan, Tangshan 063300, China.
Jingsi YanScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Xiaolang WuScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Dongsheng YuanScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Qi WangScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Huilin LiDepartment of Endocrinology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China.
Wei ZhaoScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Apolipoprotein E (ApoE) serves as a critical molecular nexus between Alzheimer's disease (AD) and atherosclerosis, two age-associated inflammatory disorders that share vascular pathology, amyloid-beta (Aβ) deposition, and lipid dysregulation. Atractylenolide I (AI), a promising therapeutic candidate derived from

Indexed as

Alzheimer’s diseaseApoE micearginine biosynthesisatractylenolide Ilipid homeostasis

Identifiers

PMID41877626
PMCPMC13191469

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.