Evidence map›Paper›PMID 41877551›Full record

ArticleCNS oncology2026

Diffuse pediatric-type high grade glioma, RTK1 subtype, subclass C with

Mikaela N Brentlinger, Jemini Patel, Ahmed Khan, Eduardo Castro-Echeverry, Zied Abdullaev, Kenneth Aldape, Norman L Lehman

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PubMed Full text at PMC Publisher
In one paragraph

Article in CNS oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mikaela N BrentlingerDepartment of Pathology and Laboratory Medicine, Baylor Scott & White Hospital, Baylor College of Medicine, Temple, TX, USA.
Jemini PatelDepartment of Pathology and Laboratory Medicine, Baylor Scott & White Hospital, Baylor College of Medicine, Temple, TX, USA.
Ahmed KhanDepartment of Pathology and Laboratory Medicine, Baylor Scott & White Hospital, Baylor College of Medicine, Temple, TX, USA.
Eduardo Castro-EcheverryDepartment of Pathology and Laboratory Medicine, Baylor Scott & White Hospital, Baylor College of Medicine, Temple, TX, USA.
Zied AbdullaevLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Kenneth AldapeLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Norman L LehmanDepartment of Pathology and Laboratory Medicine, Baylor Scott & White Hospital, Baylor College of Medicine, Temple, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abstract: Diffuse pediatric-type high-grade glioma (pHGG), RTK1 subtype, is an uncommon aggressive tumor affecting both children and adults. We describe the case of a 66-year-old woman who presented with a left frontal lobe mass. Following surgical resection, the patient developed herpes simplex virus 2 meningoencephalitis, resulting in death. Histological examination revealed a high-grade glioma demonstrating nuclear pleomorphism, high mitotic activity, vascular proliferation and necrosis. The tumor also exhibited oligodendroglial-like features, nuclear clusters and small true rosette-like structures. Genetic analysis identified partial arm 1p loss and 19q loss, Article Highlights: We report a case of diffuse pediatric-type high-grade glioma (pHGG), RTK1 subtype, subclass C  in an adult confirmed by genomic DNA methylation analysis. The tumor demonstrated

Indexed as

Brain NeoplasmsGliomaAgedFemaleHumansATRX mutationDiffuse pediatric-type high-grade gliomagenomic DNA methylation analysisMDM4 amplificationMYCN amplificationPDGFRA amplificationRTK1 subtypesubclass CSYN2::PPARG gene fusion

Identifiers

PMID41877551
PMCPMC13020859

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.