Evidence map›Paper›PMID 41877527›Full record

ArticlePhysiological reports2026

The effects of the "living high-training low" model on key proteins involved in cellular aerobic and anaerobic metabolism in male C57BL/6J mice.

Pedro P M Scariot, Marcelo Papoti, Emanuel E C Polisel, Juan B Orsi, David W Hill, Fúlvia B Manchado-Gobatto, Claudio A Gobatto

Abstract read
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In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pedro P M ScariotLaboratory of Applied Sport Physiology, University of Campinas-UNICAMP, Limeira, Sao Paulo, Brazil.ORCID https://orcid.org/0000-0003-2976-8999
Marcelo PapotiHypoxia, Sport and Health Team-HSHT, Campinas, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-3702-7149
Emanuel E C PoliselLaboratory of Applied Sport Physiology, University of Campinas-UNICAMP, Limeira, Sao Paulo, Brazil.ORCID https://orcid.org/0000-0001-5822-4566
Juan B OrsiLaboratory of Applied Sport Physiology, University of Campinas-UNICAMP, Limeira, Sao Paulo, Brazil.ORCID https://orcid.org/0000-0002-9605-661X
David W HillHypoxia, Sport and Health Team-HSHT, Campinas, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-2762-939X
Fúlvia B Manchado-GobattoLaboratory of Applied Sport Physiology, University of Campinas-UNICAMP, Limeira, Sao Paulo, Brazil.ORCID https://orcid.org/0000-0002-1178-570X
Claudio A GobattoLaboratory of Applied Sport Physiology, University of Campinas-UNICAMP, Limeira, Sao Paulo, Brazil.ORCID https://orcid.org/0000-0002-1441-7582

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 302827/2015-3Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 307395/2013-8Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 444434/2024-0Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2015/00272-6Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2015/01362-9Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2017/10201-4Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2019/05115-7Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2023/02728-3
6 · The paper itself

Abstract

This study aimed to investigate the effects of the "living high-training low" (LHTL) model, in which mice were housed under hypoxic conditions but trained in normoxia to maintain training quality. We analyzed key proteins involved in cellular metabolism and oxidative stress, including hypoxia-inducible factor 1α (HIF-1α), peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α), and oxidation resistance protein 1 (OXR1). Forty male isogenic C57BL/6J mice were divided into nontrained (N) and trained (T) groups living in normoxic (NOR) or hypoxic (HYP) environments. HYP mice were housed 18 h/day for 8 weeks in a normobaric tent supplied with oxygen-depleted air (FiO

Indexed as

HypoxiaPhysical Conditioning, AnimalAnaerobiosisAnimalsHypothalamusHypoxia-Inducible Factor 1, alpha SubunitMaleMiceMice, Inbred C57BLMuscle, SkeletalPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mousehypoxiamiceprotein expressiontraining

Identifiers

PMID41877527
PMCPMC13097600

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.