Evidence map›Paper›PMID 41877405›Full record

ArticleMolecular pain

Interaction of chronic daily headache, dietary intake of iron, and FTO genotype.

Yeganeh Shekari, Zahra Mahmoodi, Mohammadtaghi Ghorbani Hesari, Parsa Bahmani, Shailin Abdoli Rezaei, Abdolrahman Parhiz, Masoomeh Alsadat Mirshafaei, Fatemeh Sadat Fahimzad, Faezeh Varmazyar, Saeid Doaei and 1 more

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Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

11 authors.

Yeganeh ShekariDepartment of Exercise physiology, Islamic Azad University, Tabriz, Iran.
Zahra MahmoodiDepartment of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Mohammadtaghi Ghorbani HesariMashhad University of Medical Sciences, Mashhad, Iran.
Parsa BahmaniDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Shailin Abdoli RezaeiDepartment of Clinical Nutrition, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abdolrahman ParhizEducational Measurement and Evaluation, Kish International Campus, University of Tehran, Kish, Iran.
Masoomeh Alsadat MirshafaeiDepartment of Sport Physiology, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran.
Fatemeh Sadat FahimzadDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Faezeh VarmazyarIslamic Azad University, Science and Research Branch, Tehran, Iran.
Saeid DoaeiDepartment of Community Nutrition, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-1337-4963
Maryam GholamalizadehNational Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic daily headache (CDH) is known to be a common and debilitating disease that is influenced by genetic, dietary, and lifestyle factors. Iron (Fe) plays a key role in energy metabolism and neurotransmitter synthesis, while the FTO gene polymorphism (rs9939609) may play a role in modulating nutritional responses and nutrient metabolism. This study aimed to determine the interaction between CDH odds, dietary iron intake, and FTO genotype.

methodsThis case-control study was conducted on 150 CDH patients and 150 healthy individuals aged 40-80 years. Participants were assessed for anthropometric measurements, assessment of food intake using a validated food frequency questionnaire, and FTO genotype. The association between dietary iron intake and CDH stratified by FTO genotype was assessed using logistic regression analysis after adjusting for age, gender, body mass index (BMI), physical activity, energy intake, and hypertension.

resultsAmong individuals with AT/AA genotypes, those with CDH had lower dietary iron intake than controls (17.10 ± 4.02 vs 18.63 ± 4.62 mg/day,

conclusionDietary iron intake may be associated with a reduced odds of CDH in FTO A allele carriers, but no association was observed in TT genotype carriers, suggesting a gene-nutrient interaction in the prevention and management of CDH. Further studies are necessary to substantiate these findings.

Indexed as

Alpha-Ketoglutarate-Dependent Dioxygenase FTOGenetic Predisposition to DiseaseIron, DietaryAdultAgedAged, 80 and overCase-Control StudiesFemaleGenotypeHumansMaleMiddle AgedPolymorphism, Single NucleotideAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanIron, DietaryChronic headachedietary intakeFTO genegenotypeironpolymorphism

Identifiers

PMID41877405
PMCPMC13176552

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.