Evidence map›Paper›PMID 41877402›Full record

Observational studyInternational journal of stroke : official journal of the International Stroke Society2026

Timing of insertable cardiac monitor implantation after embolic stroke of undetermined source and its impact on atrial fibrillation detection: A target trial emulation analysis.

Lucio D'Anna, Fionn Maguidhir, Robert Simister, Arvind Chandratheva, Gaurav Desai, Maryam Haneef, Anne Idian, Francesco Favruzzo, Alessandra Pes, Claudio Baracchini and 29 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of stroke : official journal of the International Stroke Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Atrial fibrillation detected after stroke: Recent advances and future directions.International journal of stroke : official journal of the International Stroke Society · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors.

Lucio D'AnnaDepartment of Stroke and Neuroscience, Charing Cross Hospital, Imperial College London NHS Healthcare Trust, London, UK.ORCID 0000-0002-4349-3322
Fionn MaguidhirDepartment of Stroke and Neuroscience, Charing Cross Hospital, Imperial College London NHS Healthcare Trust, London, UK.
Robert SimisterComprehensive Stroke Service, University College London Hospital, London, UK.
Arvind ChandrathevaComprehensive Stroke Service, University College London Hospital, London, UK.ORCID 0000-0003-4967-3508
Gaurav DesaiComprehensive Stroke Service, University College London Hospital, London, UK.
Maryam HaneefComprehensive Stroke Service, University College London Hospital, London, UK.
Anne IdianComprehensive Stroke Service, University College London Hospital, London, UK.
Francesco FavruzzoStroke Unit and Neurosonology Laboratory, Padua University School of Medicine, Padua, Italy.ORCID 0000-0001-8548-6027
Alessandra PesStroke Unit and Neurosonology Laboratory, Padua University School of Medicine, Padua, Italy.
Claudio BaracchiniStroke Unit and Neurosonology Laboratory, Padua University School of Medicine, Padua, Italy.
Diletta RosinClinical Neurology, Udine University Hospital and Department of Medicine (DAME), University of Udine, Udine, Italy.
Mariarosaria ValenteClinical Neurology, Udine University Hospital and Department of Medicine (DAME), University of Udine, Udine, Italy.
Gian Luigi GigliClinical Neurology, Udine University Hospital and Department of Medicine (DAME), University of Udine, Udine, Italy.
Liqun ZhangDepartment of Neuroscience, George's University of London, Stroke, London, UK.
Nathan Leung MresDepartment of Neuroscience, George's University of London, Stroke, London, UK.
Manav SohalDepartment of Cardiology, St George's University Hospital NHS Foundation Trust, London, UK.
Simona SaccoDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Raffaele OrnelloDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.ORCID 0000-0001-9501-4031
Federico De SantisDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.ORCID 0000-0002-8059-6427
Ubaldo CoppolaDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Gabriele PrandinDepartment of Brain Sciences, Imperial College London, London, UK.ORCID 0000-0002-5698-4737
Selina EdwardsComprehensive Stroke Service, University College London Hospital, London, UK.
Ceylan SafakComprehensive Stroke Service, University College London Hospital, London, UK.
Roberto AvilaComprehensive Stroke Service, University College London Hospital, London, UK.
Joan CruzComprehensive Stroke Service, University College London Hospital, London, UK.
Ashley LaurieComprehensive Stroke Service, University College London Hospital, London, UK.
Michele RomoliDepartment of Neuroscience, Neurology and Stroke Unit, Bufalini Hospital, Cesena, Italy.
Valentina TudiscoDepartment of Neuroscience, Neurology and Stroke Unit, Bufalini Hospital, Cesena, Italy.
Federica Nicoletta SepeDepartment of Neuroscience, Neurology and Stroke Unit, Bufalini Hospital, Cesena, Italy.
Jianqun GuanDepartment of Cardiology, Hammersmith Hospital, Imperial College London NHS Healthcare Trust, London, UK.
Asha BarnardDepartment of Cardiology, Hammersmith Hospital, Imperial College London NHS Healthcare Trust, London, UK.
Lydia JeffreyDepartment of Cardiology, Hammersmith Hospital, Imperial College London NHS Healthcare Trust, London, UK.
Jake DaganDepartment of Cardiology, Hammersmith Hospital, Imperial College London NHS Healthcare Trust, London, UK.
Tsering DolkarDepartment of Stroke and Neuroscience, Charing Cross Hospital, Imperial College London NHS Healthcare Trust, London, UK.
Jonathan HaytonDepartment of Stroke and Neuroscience, Charing Cross Hospital, Imperial College London NHS Healthcare Trust, London, UK.
Soma BanerjeeDepartment of Stroke and Neuroscience, Charing Cross Hospital, Imperial College London NHS Healthcare Trust, London, UK.
Matteo FoschiDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.ORCID 0000-0002-0321-7155
Giovanni MerlinoClinical Neurology, Udine University Hospital and Department of Medicine (DAME), University of Udine, Udine, Italy.
Phang Boon LimDepartment of Cardiology, Hammersmith Hospital, Imperial College London NHS Healthcare Trust, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA substantial proportion of ischemic strokes remain classified as embolic stroke of undetermined source (ESUS) despite standard diagnostic evaluation. Prolonged cardiac monitoring with implantable cardiac monitors (ICMs) increases atrial fibrillation (AF) detection, but the optimal timing of ICM implantation after ESUS remains uncertain.

aimsTo evaluate whether early versus delayed ICM implantation after ESUS influences AF detection and time to diagnosis.

methodsWe conducted a multicenter observational cohort study emulating a target trial. Consecutive ESUS patients undergoing ICM implantation were classified as ICM

resultsAmong 333 patients (90 ICM

conclusionEarly ICM implantation after ESUS is associated with higher and faster AF detection compared with delayed implantation. When ICM monitoring is indicated, avoiding unnecessary delays may substantially enhance diagnostic yield.

Indexed as

Atrial FibrillationElectrocardiography, AmbulatoryEmbolic StrokeAgedAged, 80 and overCohort StudiesFemaleHumansMaleMiddle AgedTime FactorsTreatment Delayatrial fibrillationESUSICMtiming

Identifiers

PMID41877402
PMCPMC13392176

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.