Evidence map›Paper›PMID 41877401›Full record

ArticleJournal of veterinary pharmacology and therapeutics2026

Ocular Pharmacokinetics of Topical Chloramphenicol in Dogs: Effects of Concentration and Vehicle Formulation.

Bar Fruchter, Oren Pe'er, Shir Gonen, Lionel Sebbag

Abstract readComparative StudyRandomized Controlled Trial, Veterinary
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary pharmacology and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bar FruchterKoret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel.
Oren Pe'erKoret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel.
Shir GonenKoret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel.
Lionel SebbagKoret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel.ORCID https://orcid.org/0000-0002-0103-0127

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study compared tear film exposure and retention of four chloramphenicol ophthalmic formulations in dogs, evaluating the effects of drug concentration (0.2% to 5%) and vehicle type (solution vs. ointment). Eight healthy dogs were enrolled in a randomized paired-eye crossover study consisting of two sessions with a 7-day washout. Tear samples were collected via microcapillary tubes at intervals up to 480 min post-instillation, and concentrations were quantified using UV-Vis spectrophotometry. Results showed that chloramphenicol exposure was significantly enhanced by higher concentrations and ointment vehicles. The 0.8% solution achieved a 2.2-fold increase in AUC

Indexed as

Anti-Bacterial AgentsChloramphenicolDogsEyeAdministration, OphthalmicAdministration, TopicalAnimalsArea Under CurveCross-Over StudiesDose-Response Relationship, DrugFemaleMaleOintmentsOphthalmic SolutionsTearsAnti-Bacterial AgentsChloramphenicolOintmentsOphthalmic Solutionsantibiotic therapybacterial keratitisocular drug deliveryophthalmic ointmentophthalmic solutionpharmacokinetics

Identifiers

PMID41877401
PMCPMC13371850

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.