Evidence map›Paper›PMID 41877394›Full record

ArticleMolecular pain

The enhanced analgesic effects of electroacupuncture and repetitive transcranial magnetic stimulation on visceral pain via ventral lateral septal nucleus.

Rui-Xia Weng, Yuan Gao, Chen-Hao Zhang, Ru-Yu Yan, Qi Liu, Zhen-Hua Xu, Hua-Zheng Wang, Rui Li, Rong Gao, Yong-Chang Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rui-Xia WengJiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Department of Gastroenterology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Yuan GaoJiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Department of Gastroenterology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Chen-Hao ZhangJiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Department of Gastroenterology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Ru-Yu YanJiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Department of Gastroenterology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Qi LiuJiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Department of Gastroenterology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Zhen-Hua XuTranslational Medicine Center, The Affiliated Zhangjiagang Hospital of Soochow University, Zhangjiagang, P.R. China.
Hua-Zheng WangThe Affiliated BenQ Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.
Rui LiJiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Department of Gastroenterology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Rong GaoTranslational Medicine Center, The Affiliated Zhangjiagang Hospital of Soochow University, Zhangjiagang, P.R. China.
Yong-Chang LiJiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Department of Gastroenterology, the First Affiliated Hospital of Soochow University, Suzhou, China.ORCID 0009-0007-8694-5150
Guang-Yin XuJiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Department of Gastroenterology, the First Affiliated Hospital of Soochow University, Suzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized primarily by chronic visceral pain, with a complex pathogenesis and limited efficacy of current therapeutic interventions. Growing evidence indicates that electroacupuncture (EA) and repetitive transcranial magnetic stimulation (rTMS) exert significant analgesic effects on visceral pain. However, the underlying neural circuit mechanisms remain poorly understood. In this study, the ventral part of the lateral septal nucleus (LSV) was identified as a critical brain region mediating the analgesic effects of EA and rTMS in a mouse model of visceral pain. Visceral nociceptive stimulation significantly increased c-Fos expression in the LSV, predominantly within glutamatergic (Glu

Indexed as

ElectroacupunctureSeptal NucleiTranscranial Magnetic StimulationVisceral PainAnimalsGlutamic AcidMaleMiceMice, Inbred C57BLNeuronsProto-Oncogene Proteins c-fosGlutamic AcidProto-Oncogene Proteins c-foschronic visceral painelectroacupunctureIrritable bowel syndromerepetitive transcranial magnetic stimulationventral part of lateral septal nucleus

Identifiers

PMID41877394
PMCPMC13087329

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.