ReviewJournal of cosmetic dermatology2026
Research Progress on Platelet-Rich Plasma (PRP) in the Treatment of Androgenetic Alopecia.
Review in Journal of cosmetic dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Efficacy and Safety of Platelet-Rich Plasma Versus Topical Minoxidil in Androgenetic Alopecia: A Systematic Review.Cureus · 2026Review
- Extracellular Vesicles for Androgenetic Alopecia: Current Evidence, Mechanisms, and Clinical Prospects.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundAndrogenetic alopecia (AGA) is the most common cause of progressive hair loss, significantly affecting quality of life. Current therapies, such as minoxidil, finasteride, and hair transplantation, show variable efficacy and may be associated with adverse effects. Platelet-rich plasma (PRP), an autologous preparation enriched with platelets and growth factors, has recently gained attention as a regenerative option for hair restoration.
objectiveThis review summarizes advances in PRP therapy for AGA, focusing on preparation techniques, mechanisms of action, clinical efficacy, and safety, and provides recommendations for protocol optimization and future research.
methodsA systematic search of PubMed, Web of Science, Embase, Cochrane Library, and CNKI was conducted for studies published between 2000 and 2025. Eligible articles included randomized controlled trials, cohort studies, case-control studies, and meta-analyses evaluating PRP preparation methods or therapeutic outcomes. Study quality was appraised using the Cochrane Risk of Bias, ROBINS-I, and GRADE frameworks.
resultsPRP promotes follicular regeneration through angiogenesis and activation of Wnt/β-catenin, MAPK, Akt/ERK, and Notch signaling pathways. Clinical trials demonstrate improved hair density, thickness, and patient satisfaction, particularly when PRP is combined with minoxidil, microneedling, or laser therapy. Reported adverse events are mild and transient, such as localized pain or erythema. Nevertheless, heterogeneity in centrifugation, activation, and delivery protocols contributes to inconsistent outcomes across studies.
conclusionPRP represents a promising, safe, and minimally invasive therapy for AGA. Establishing standardized preparation protocols and conducting large-scale randomized studies are essential to confirm long-term efficacy and integrate PRP into routine, personalized AGA management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.