Evidence map›Paper›PMID 41877356›Full record

ArticleRenal failure2026

Loss of NGAL protects against albumin-induced kidney inflammation and fibrosis.

Stefanny M Figueroa, Javier Reyes Osorio, Safia Hadjadj, Gabriela Arenas, Patricio Araos, Perrine Frère, Rodrigo Pacheco, Christos E Chadjichristos, Cristián A Amador

Abstract read
In one paragraph

Article in Renal failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Stefanny M FigueroaFacultad de Ciencias, Universidad San Sebastián, Santiago, Chile.ORCID 0000-0002-6343-9163
Javier Reyes OsorioFacultad de Ciencias, Universidad San Sebastián, Santiago, Chile.ORCID 0000-0001-8297-0833
Safia HadjadjINSERM, Common and Rare Kidney Diseases: From Molecular Events to Precision Medicine, CoRaKiD, Sorbonne Université, Paris, France.ORCID 0009-0000-5287-7515
Gabriela ArenasFacultad de Ciencias, Universidad San Sebastián, Santiago, Chile.ORCID 0009-0006-8289-6120
Patricio AraosHypertension and Kidney Immunology Laboratory, Faculty of Health Sciences, Institute of Biomedical Sciences, Universidad Autónoma de Chile, Santiago, Chile.ORCID 0000-0001-5089-5998
Perrine FrèreINSERM, Common and Rare Kidney Diseases: From Molecular Events to Precision Medicine, CoRaKiD, Sorbonne Université, Paris, France.ORCID 0000-0001-9660-2935
Rodrigo PachecoFacultad de Ciencias, Universidad San Sebastián, Santiago, Chile.ORCID 0000-0001-8057-9806
Christos E ChadjichristosINSERM, Common and Rare Kidney Diseases: From Molecular Events to Precision Medicine, CoRaKiD, Sorbonne Université, Paris, France.ORCID 0000-0001-6657-7900
Cristián A AmadorFacultad de Ciencias, Universidad San Sebastián, Santiago, Chile.ORCID 0000-0001-6802-6811

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increased albuminuria represents a risk factor for chronic kidney disease (CKD), and it is associated with the development and progression of kidney inflammation and fibrosis. The expression of neutrophil gelatinase-associated lipocalin (NGAL), a biomarker for kidney damage, is increased in CKD patients and experimental animal models of kidney damage. However, it is unknown whether NGAL is necessary for the promotion of kidney inflammation and fibrosis associated with the albumin exposition. Male C57BL6/J wild-type (WT) and NGAL (knockout) KO mice (8-12 weeks,

Indexed as

Acute-Phase ProteinsAlbuminuriaKidneyLipocalinsProto-Oncogene ProteinsAlbuminsAnimalsDisease Models, AnimalFibrosisInflammationLipocalin-2MaleMiceMice, Inbred C57BLMice, KnockoutTumor Necrosis Factor-alphaAcute-Phase ProteinsAlbuminsLcn2 protein, mouseLipocalin-2LipocalinsProto-Oncogene ProteinsTumor Necrosis Factor-alphaAlbuminCKDfibrosisinflammationNGAL

Identifiers

PMID41877356
PMCPMC13021016

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.