Evidence map›Paper›PMID 41877348›Full record

Observational studyCancer medicine2026

Qualitative Study of Breast Cancer and Lymphoma Patients Participating in a Physical Activity Intervention: The Case for Tailored Physical Activity.

Brianna N Leitzelar, Juliana V Costa, Aylin A Aguilar, Brianna R Wolle, Alexander R Lucas, Alexandra Marshall, Sam Norton, Shannon L Mihalko, Peter H Brubaker, Rakhee Vaidya and 6 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01719562 (Improving Exercise Capacity With a Tailored Physical Activity Intervention in Lymphoma and Breast Cancer Patients Undergoing Treatment - An Addendum to NIH R01CA167821 "Early Imaging Detection of Cardiovascular Injury After Cancer"), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01719562 nacompletednot on this map

Improving Exercise Capacity With a Tailored Physical Activity Intervention in Lymphoma and Breast Cancer Patients Undergoing Treatment - An Addendum to NIH R01CA167821 "Early Imaging Detection of Cardiovascular Injury After Cancer"

TypeinterventionalSponsorWake Forest University Health SciencesRan2013 to 2022Enrolled28ConditionsCardiac Toxicity, Malignant Neoplasm, Breast CancerArmsMagnetic resonance imaging, Physical Activity, Healthy Living, Cardiopulmonary Exercise Testing (CPET), Questionnaire Administration
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Brianna N LeitzelarDepartment of Social Sciences and Health Policy, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID https://orcid.org/0000-0003-0406-0118
Juliana V CostaDepartment of Health and Exercise Science, Worrell Professional Center, Wake Forest University, Winston-Salem, North Carolina, USA.
Aylin A AguilarQualitative and Patient-Reported Outcomes Shared Resource, Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, USA.
Brianna R WolleDepartment of Health and Exercise Science, Worrell Professional Center, Wake Forest University, Winston-Salem, North Carolina, USA.
Alexander R LucasDepartment of Internal Medicine-Cardiology, Virginia Commonwealth University, Richmond, Virginia, USA.ORCID https://orcid.org/0000-0001-7318-3387
Alexandra MarshallDepartment of Internal Medicine-Cardiology, Virginia Commonwealth University, Richmond, Virginia, USA.
Sam NortonDepartment of Health and Exercise Science, Worrell Professional Center, Wake Forest University, Winston-Salem, North Carolina, USA.
Shannon L MihalkoDepartment of Social Sciences and Health Policy, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Peter H BrubakerDepartment of Health and Exercise Science, Worrell Professional Center, Wake Forest University, Winston-Salem, North Carolina, USA.
Rakhee VaidyaDepartment of Internal Medicine (Section on Hematology-Oncology), Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Mary Beth SeegarsDepartment of Internal Medicine (Section on Hematology-Oncology), Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Victor YazbeckMassey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, USA.
R Lee FrancoDepartment of Kinesiology and Health Sciences, Virginia Commonwealth University, Richmond, Virginia, USA.
Jeremy ViaDepartment of Kinesiology and Health Sciences, Virginia Commonwealth University, Richmond, Virginia, USA.ORCID https://orcid.org/0000-0002-5363-6155
W Gregory HundleyDepartment of Internal Medicine-Cardiology, Virginia Commonwealth University, Richmond, Virginia, USA.
Lynne I WagnerDepartment of Health Policy and Management, University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0001-9685-4796

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Improving Exercise Capacity with a Tailored Physical Activity Intervention in Lymphoma Patients Undergoing TreatmentR21CA226960 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUNDLEY, WILLIAM GREGORY, VAIDYA, RAKHEE · 2019 to 2020
$373k
NCI NIH HHS CA122061NCI NIH HHS CA226960NCI NIH HHS P30 CA012197NCI NIH HHS P30CA12197NCI NIH HHS R21 CA226960
6 · The paper itself

Abstract

backgroundExercise mitigates chemotherapy-related cardiotoxicity, but implementing exercise interventions during chemotherapy treatment can be challenging. Understanding the patient perspective can help refine exercise programs and facilitate successful implementation of future interventions. PURPOSE: To utilize qualitative data to optimize adherence and retention for a future randomized clinical trial involving a tailored physical activity (PA) intervention among breast cancer and lymphoma patients receiving potentially cardiotoxic chemotherapy.

methodsEighteen breast cancer and lymphoma patients receiving potentially cardiotoxic chemotherapy who enrolled in a PA intervention completed semi-structured interviews. Interviews focused on reasons for enrollment or dropout, perceptions of study personnel, experiences within the study interventions, and barriers to intervention adherence. Interviews were audio recorded. Key points and potential themes were identified using an integrative synthesis of the data.

resultsParticipants were on average 53 years (SD = 15) old, were 50% female (n = 9), predominantly identified as White (n = 15, 83%), and were mostly non-Hodgkin Lymphoma patients (n = 11, 61%). The main reasons for enrollment were altruism and provider recommendation. Participants stated they completed the study because of intrinsic motivation, ease of participation, and positive study experiences. Participants reported favorable perceptions of the study interventions and study staff. Barriers to adherence included symptom burden and lack of motivation.

conclusionsMessages to enhance altruism and collaboration with providers may be important recruitment tools. Developing positive study-staff relationships and delivering tailored, flexible interventions may enhance study adherence and retention. Ultimately, these strategies contribute to the successful implementation of cancer exercise trials. TRIALS REGISTRATION: NCT01719562.

Indexed as

Breast NeoplasmsExerciseExercise TherapyLymphomaAdherence InterventionsAdultAgedCardiotoxicityFemaleHumansMaleMiddle AgedMulticenter Studies as TopicPatient ComplianceQualitative ResearchRandomized Controlled Trials as Topicbreast cancercardiotoxicityexerciselymphomaparticipant perspectivesqualitative research

Identifiers

PMID41877348
PMCPMC13140851

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.