ArticleTrials2026
Effects of combined cerebellar tACS-iTBS in individuals with ataxia (EtABeta): a crossover investigation.
Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06420271 (Effects of Combined Transcranial Electrical and Magnetic Stimulation of Cerebellum on Balance Function in Ataxia Patients), which is not on this map. Not yet cited in PubMed.
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Effects of Combined Transcranial Electrical and Magnetic Stimulation of Cerebellum on Balance Function in Ataxia Patients
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Authors and funding
13 authors.
Funding
Abstract
backgroundCerebellar ataxia (CA) is a neurodegenerative disorder characterized by progressive impairments in coordination, balance, and gait disturbances. Conventional rehabilitation therapies offer only limited benefits, driving interest toward exploring alternative non-invasive interventions. Among these, non-invasive brain stimulation techniques, such as cerebellar transcranial alternating current stimulation (tACS) and intermittent theta burst stimulation (iTBS) have emerged as promising approaches. This study aims to investigate the effectiveness of a combined cerebellar tACS-iTBS protocol in alleviating symptoms of CA, specifically targeting improvements in motor coordination, balance control, and quality of life.
methodsIn this randomized, sham-controlled crossover study, 31 patients diagnosed with CA will participate in two experimental conditions (real and sham stimulation), each lasting 2 weeks (phase A and B) and separated by a 3-week washout period. In the real condition, patients will receive cerebellar tACS at 5 Hz (2 mA, 190 s) delivered simultaneously with iTBS (600 pulses at 50 Hz; 80% of active motor threshold). In the sham condition, TMS will be applied without active stimulation, and cerebellar tACS will be applied only briefly for participant blinding. Following each stimulation session, patients will perform sensor-based balance training using an adaptive system with a force platform for a total of 30 min. Outcome assessments will take place at baseline of each phase (A and B) (T0 DISCUSSION: This study will provide valuable insights into the therapeutic potential of cerebellar tACS-iTBS as a non-invasive intervention for CA. By assessing its effects on balance, coordination, and overall quality of life, the findings could help establish whether this combined stimulation method serves as a beneficial aid to sensor-based balance training. If successful, cerebellar tACS-iTBS could offer a promising new strategy to enhance clinical outcomes and improve the quality of life in individuals with CA.
trial registrationClinicalTrial.gov NCT06420271. Registered on 2024-05-20.
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