Evidence map›Paper›PMID 41877249›Full record

ReviewItalian journal of pediatrics2026

Bridging eosinophilic esophagitis: healthcare transition from pediatric to adult patients.

Edoardo Vincenzo Savarino, Roberta Giodice, Marianna Morani, Marzia Bonfanti, Martina Fardella, Maria Beatrice Bilò, Nicola De Bortoli, Antonio Di Sabatino, Roberto Penagini, Francesca Rea and 7 more

Abstract readReview
In one paragraph

Review in Italian journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Edoardo Vincenzo SavarinoDepartment of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.
Roberta GiodicePresident ESEO (Association of Families Against Eosinophilic Esophagitis), Bracciano (Rome), Italy.
Marianna MoraniPharmaLex Italy S.p.A., Milan, Italy. marianna.morani@pharmalex.com.ORCID http://orcid.org/0009-0009-0548-6226
Marzia BonfantiPharmaLex Italy S.p.A., Milan, Italy.
Martina FardellaPharmaLex Italy S.p.A., Milan, Italy.
Maria Beatrice BilòDepartment of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.
Nicola De BortoliGastroenterology Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Antonio Di SabatinoDepartment of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, Italy.
Roberto PenaginiGastroenterology and Endoscopy Division, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Francesca ReaPaediatric Gastroenterology and Nutrition Unit, Bambino Gesu Children's Hospital, Rome, Italy.
Sara RenzoGastroenterology and Nutrition Unit, Meyer Children's Hospital IRCCS, Florence, Italy.
Claudio RomanoDepartment of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Messina, Italy.
Giovanni SarnelliDepartment of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Irene SpinelliDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
Caterina StrisciuglioDepartment of Woman, Child and General and Specialized Surgery of the University of Campania "Luigi Vanvitelli", Naples, Italy.
Edoardo VespaGastroenterology and Digestive Endoscopy, Motility Unit, IRCCS Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy.
Salvatore OlivaPaediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, University Hospital - Umberto I, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eosinophilic esophagitis (EoE) is a chronic and progressive type 2 immune-mediated disease resulting in esophageal dysfunction. As with other chronic conditions, therapeutic continuity is crucial to ensure patient benefits, particularly during the transition of patients with EoE from pediatric to adult care. This investigation aimed to establish an algorithm to assist healthcare providers in optimizing the healthcare transition pathway through a multistep collaborative process that encompassed an initial analysis of the three principal currently available guidelines, the formulation of recommendations by a steering committee, and their validation through deliberation with a panel of 11 Italian EoE experts. Three essential criteria have been elucidated to define the healthcare transition pathway for pediatric patients with EoE to adulthood: readiness to transition, patient’s age, and disease control (from clinical, endoscopic, and histological perspectives). The algorithm incorporates the utilization of the STARx questionnaire as an efficacious instrument to assess patient’s readiness to transition, identifies the optimal age for this phase within the range of 14–18 years, and considers clinical, endoscopic, and histological control maintained for a minimum of 6 months. The availability of a standardized and well-defined pathway supporting healthcare professionals during the transition process of pediatric EoE patients to adulthood is associated with therapeutic continuity, enhancement of clinical outcomes, and prevention of long-term fibrostenotic complications, which may result in economic benefits for the Italian health system.

Indexed as

Eosinophilic EsophagitisTransition to Adult CareAdolescentAdultAlgorithmsChildFemaleHumansItalyMaleEosinophilic esophagitisHealthcare transitionPatients readinessSTARx questionnaireTransitional care

Identifiers

PMID41877249
PMCPMC13137597

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.