Evidence map›Paper›PMID 41877162›Full record

ArticleBMC biology2026

The first chromosome-level cubozoan genome differentiates unique and common features in different cnidarian lineages.

Sean T S Law, Yiqian Li, Chade Li, Wenyan Nong, Kam Ling Chan, Carmen Or, Jian-Wen Qiu, Jerome H L Hui

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In one paragraph

Article in BMC biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sean T S Law *School of Life Sciences, Institute of Environment, Energy and Sustainability, State Key Laboratory of Agrobiotechnology, Simon F.S. Li Marine Science Laboratory, The Chinese University of Hong Kong, Hong Kong SAR, China.
Yiqian Li *School of Life Sciences, Institute of Environment, Energy and Sustainability, State Key Laboratory of Agrobiotechnology, Simon F.S. Li Marine Science Laboratory, The Chinese University of Hong Kong, Hong Kong SAR, China.
Chade LiSchool of Life Sciences, Institute of Environment, Energy and Sustainability, State Key Laboratory of Agrobiotechnology, Simon F.S. Li Marine Science Laboratory, The Chinese University of Hong Kong, Hong Kong SAR, China.
Wenyan NongSchool of Life Sciences, Institute of Environment, Energy and Sustainability, State Key Laboratory of Agrobiotechnology, Simon F.S. Li Marine Science Laboratory, The Chinese University of Hong Kong, Hong Kong SAR, China.
Kam Ling ChanSchool of Life Sciences, Institute of Environment, Energy and Sustainability, State Key Laboratory of Agrobiotechnology, Simon F.S. Li Marine Science Laboratory, The Chinese University of Hong Kong, Hong Kong SAR, China.
Carmen OrWWF-Hong Kong, Hong Kong SAR, China.
Jian-Wen QiuDepartment of Biology, Hong Kong Baptist University, Hong Kong SAR, China. qiujw@hkbu.edu.hk.
Jerome H L HuiSchool of Life Sciences, Institute of Environment, Energy and Sustainability, State Key Laboratory of Agrobiotechnology, Simon F.S. Li Marine Science Laboratory, The Chinese University of Hong Kong, Hong Kong SAR, China. jeromehui@cuhk.edu.hk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCnidarians are aquatic invertebrates that can be found in both freshwater and marine habitats, including the corals, sea anemones, hydroids, true jellyfish (scyphozoans), and box jellyfish (cubozoans). Despite most cnidarian groups already having representative genomic resources, a high-quality genome of the cubozoan remains lacking.

resultsHere, we obtained the first chromosomal-level genome of the box jellyfish Tripedalia maipoensis, having a genome assembly size of 637.8 Mb and a scaffold N50 of 47.1 Mb. By comparing the cubozoan genome to other cnidarian lineages, unique and common features of cnidarians, including cnidarian-specific opsins, toxins, neuropeptides, sesquiterpenoid hormones, and microRNAs, were revealed.

conclusionsThe high-quality genome of a cubozoan presented in this study reveals distinct cnidarian features and provides a crucial missing foundation for further understanding cnidarian evolution more broadly.

Indexed as

ChromosomesCnidariaCubozoaGenomeAnimalsMicroRNAsPhylogenyMicroRNAsBox jellyfishmicroRNAsNeuropeptidesSesquiterpenoid hormones

Identifiers

PMID41877162
PMCPMC13137736

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.