Trial reportBMC anesthesiology2026
Mechanical power during one-lung ventilation is associated with postoperative pulmonary complications in patients undergoing lobectomy: a single-center prospective cohort study.
Trial report in BMC anesthesiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundRetrospective analyses have associated elevated mechanical power (MP) during one-lung ventilation (OLV) with reintubation rates and emergent non-invasive ventilation. Nonetheless, the study design and chosen outcomes may limit the generalizability of these findings to postoperative pulmonary complications (PPCs) in patients undergoing thoracoscopic lobectomy. The aim of this study was to evaluate whether this association remained robust under a standardized anesthesia protocol.
methodA prospective cohort study was conducted at a tertiary hospital among adults aged 50-80 years. Respiratory signals, chest computed tomography, and blood sampling were routinely measured. MP was defined as the sum of the energy transferred to overcome airway resistance and temporarily stored in the elastic lung tissue in one minute. The primary endpoint was the association of MP and PPCs. The secondary endpoints were the occurrence of impaired postoperative oxygenation, changes in lung aeration compartments, and systemic inflammatory factors during the perioperative period.
resultsPatient recruitment lasted from August 1st 2022 to July 19th 2024 and included 118 participants. The incidence of PPCs was 33.9 %. MP during OLV and normalization to lung volume in non-surgical lungs, as well as the elastic and resistive components of MP, were independently associated with PPCs (ORadj =1.67 [1.01, 2.76], p =0.044; 1.68 [1.04, 2.71], p =0.033; 1.81 [1.16, 3.11], p =0.046; and 2.61 [1.09, 6.27], p =0.031, respectively). Compared with resistive components, dynamic elastic component of MP had a stronger dominance on PPCs (contribution to pseudo-R2 0.029 vs. 0.015). The relationship between MP and PPCs was non-linear (p =0.047), with a reflection point at MP of 3.7 J.min-1. Compared to those without PPCs, patients with PPCs exhibited higher perioperative IL-10 levels and consistently poor lung aeration—both preoperatively in the non-dependent region and postoperatively in the mid-ventral region. Changes in biomarkers did not differ between patients; however, IL-8 levels showed consistent associations with PPCs during the perioperative observation period.
conclusionUnder lung-protective ventilation, MP during OLV was independently and non-linearly associated with PPCs, driven predominantly by its dynamic elastic component and accompanied by specific inflammatory and aeration changes. CLINICAL
trial registrationNumber ChiCTR2200062173 (restarted on July 27th 2022).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.