Evidence map›Paper›PMID 41877000›Full record

ArticleBMC medical research methodology2026

Estimating intervention impacts when timing is unclear: an AR-LagDT model with distributed lags.

Xiangliang Zhang, Ninghui Li, Kunpeng Wu, Peng Wang, Tao Li, Pengchao An, Zuhuan Ren, Wen Chen

Abstract read
In one paragraph

Article in BMC medical research methodology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiangliang ZhangDepartment of Earth System Science, Tsinghua University, Beijing, China.
Ninghui LiDepartment of Earth System Science, Tsinghua University, Beijing, China.
Kunpeng WuDepartment of Medical Statistics, School of Public Health, Sun Yat-Sen University, Guangzhou, China.
Peng WangDepartment of Earth System Science, Tsinghua University, Beijing, China.
Tao LiDepartment of Earth System Science, Tsinghua University, Beijing, China.
Pengchao AnDepartment of Earth System Science, Tsinghua University, Beijing, China.
Zuhuan RenDepartment of Earth System Science, Tsinghua University, Beijing, China.
Wen ChenDepartment of Medical Statistics, School of Public Health, Sun Yat-Sen University, Guangzhou, China. chenw43@mail.sysu.edu.cn.

Funding

National Natural Science Foundation of China 82473731
6 · The paper itself

Abstract

Interrupted Time Series (ITS) analysis is widely used to evaluate intervention impacts, but conventional methods like the classical segmented regression (CSR) and "prediction" models (ARIMA, ETS, etc.) have limitations. CSR assumes an immediate effect, while "prediction" models rely on counterfactual estimates that become unreliable over time. To address this, we propose the Autoregressive with Lag Distributed Term (AR-LagDT) model, which explicitly accounts for intervention effect ambiguity using distributed lag functions. By incorporating varying fuzzy statuses (the onset and duration ambiguity of the intervention effect) and multiple distribution patterns, the AR-LagDT model provides more precise estimates of intervention dynamics. We validate the model through an empirical case study on Japan’s COVID-19 State of Emergency and its impact on the Human Mobility Index in Tokyo. To enhance usability, we develop a user-friendly software application for AR-LagDT model. Our findings demonstrate the model’s ability to capture the temporal progression of intervention effects, providing estimates of maximum impact, cumulative effect, and time-dependent changes. In the empirical analysis, AR-LagDT (e.g., MSE: 7.0139) demonstrate superior in-sample fit to CSR (e.g., MSE: 14.2741) while achieving a broadly similar performance level to the average of "prediction" models (e.g., MSE: 8.1845, ranging from 5.6944 to 14.1337). Moreover, the AR-LagDT model offers clearer interpretability of time-varying impacts. Despite challenges in selecting appropriate fuzzy statuses and distribution patterns, this model offers a robust and flexible framework for impact evaluations in various disciplines and enhances accessibility for researchers conducting intervention analyses in epidemiology, public health, and policy evaluation.

Indexed as

COVID-19Interrupted Time Series AnalysisModels, StatisticalAlgorithmsFuzzy LogicHumansJapanPandemicsRegression AnalysisSARS-CoV-2Time FactorsARIMAXDistributed lag functionDistribution patternEffect ambiguityInterrupted time seriesIntervention evaluationModel optimization

Identifiers

PMID41877000
PMCPMC13137659

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.