ArticleCancer medicine2026
Circulating Thrombospondin-4-Positive Fibroblasts Might be a Useful Marker for Diagnosis of Gastric Cancer.
Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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17 authors.
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Abstract
backgroundCancer-associated fibroblasts (CAFs) have been reported to be tumor-specific cells. We have recently reported that thrombospondin-4 (THBS4) expression is exclusive to CAFs. This study aimed to clarify whether the identification of circulating CAFs (cir-CAFs) by THBS4 is detectable in the blood of gastric cancer (GC) patients, and whether cir-CAFs are useful for the screening test of GC. MATERIALS AND
methodsCAFs and normal fibroblasts (NFs) were respectively established from 17 GC specimens. A total of 24 healthy volunteers and 77 GC patients were enrolled. Flow cytometric analysis was performed using anti-THBS4 antibody. The sensitivity and specificity of THBS4-positive cir-CAFs for detection of GC were calculated.
resultsTHBS4+ cells showed ovoid-like cells and expressed THBS4. THBS4
conclusionTHBS4-positive cir-CAFs are detectable in the blood of GC patients. The cir-CAFs might be a useful tumor marker in a GC screening test, especially for early-stage GC.
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