Evidence map›Paper›PMID 41876954›Full record

ArticleMagnetic resonance in medicine2026

Characterizing the Diffusion Properties of Prostate Tissue Using Paired MR Microscopy and Multidimensional Diffusion MRI.

Adam Phipps, Nyoman D Kurniawan, Geoff Watson, Paul Sved, Samson Dowland, Eleftheria Panagiotaki, David Atkinson, Roger Bourne

Abstract read
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In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adam PhippsCentre for Medical Imaging, Division of Medicine, University College London, London, UK.ORCID 0000-0002-8011-6139
Nyoman D KurniawanAustralian Institute for Bioengineering and Nanotechnology, Centre for Advanced Imaging, The University of Queensland, Brisbane, Queensland, Australia.
Geoff WatsonNew South Wales Health Pathology, Sydney, New South Wales, Australia.
Paul SvedSchool of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Samson DowlandSchool of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Eleftheria PanagiotakiHawkes Institute, University College London, London, UK.ORCID 0000-0002-2697-3447
David AtkinsonCentre for Medical Imaging, Division of Medicine, University College London, London, UK.ORCID 0000-0003-1124-6666
Roger BourneSydney School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0003-2755-089X

Funding

Engineering and Physical Sciences Research Council funded UCL Centre for Doctoral Training in Intelligent, Integrated Imaging in Healthcare (i4health) EP/S021930/1
6 · The paper itself

Abstract

purposeTo characterize the diffusion properties of prostate epithelium and stroma in benign tissue and cancer.

methodsPaired MR microscopy (20 μm) and multidimensional diffusion MRI (dMRI) (160 μm, b = 1000-2000 s/mm

resultsAggregate dMRI signal estimates for both epithelium and stroma were best described by the Ball + Sphere model (lowest AICc). A higher sphere fraction (0.278 vs. 0.175) and lower ball-compartment diffusivity (0.611 vs. 0.943 μm

conclusionDirection-averaged diffusion in fixed prostate epithelium and stroma is well described by the Ball + Sphere model. The diffusion properties of epithelium in Gleason 3 + 3 cancer and benign tissue appear to be similar; however, a marked increase to the volume fraction of restricted water was found for Gleason 4 + 4 epithelium.

Indexed as

Diffusion Magnetic Resonance ImagingMicroscopyProstateProstatic NeoplasmsAlgorithmsDiffusionEpitheliumHumansImage Processing, Computer-AssistedMale

Identifiers

PMID41876954
PMCPMC13156426

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.