ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026
Early-onset Parkinson's disease: clinical findings and progression.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study investigated the prevalence, clinical features, and treatment characteristics of early-onset Parkinson's disease (EOPD) in a tertiary centre in Turkey.
methodsMedical records of 1,878 patients diagnosed with EOPD and idiopathic Parkinson's disease (iPD) between January 2010 and August 2024 were retrospectively reviewed. Patients diagnosed with EOPD and iPD were identified. The EOPD group and the iPD group were defined as patients with an age of onset ≤ 50 years and between 50 and 70 years, respectively.
resultsThere were 388 patients in the EOPD group and 997 patients in the iPD group. The mean disease duration was significantly longer, and the Mean Hoehn-Yahr Scale (HYS) scores and the mean levodopa-equivalent dose (LEDD) were similar. In the EOPD group, there was a slight correlation between disease duration and HYS score (p < 0.000, r = 0.282). Temporal trend analyses demonstrated distinct longitudinal patterns between EOPD and iPD. In the interaction model for LDED, both groups showed a decline in LDED over time; the rate of reduction was steeper in the iPD group. For the HYS, no significant temporal change was detected, and the interaction term was non-significant, suggesting similar progression trajectories between EOPD and iPD (Table 2).
conclusionEOPD cases in our cohort have a longer disease course. Although they have a longer disease duration, the mean LEDD and motor complications are similar to those in typical PD cases. Overall, these findings highlight the clinical heterogeneity of EOPD and emphasize the importance of tailored long-term management strategies in this population.
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