Evidence map›Paper›PMID 41876888›Full record

ArticlePlant cell reports2026

Integrated multi-omics analyses elucidate the key regulatory networks in response to Tomato brown rugose fruit virus infection in Solanum lycopersicum L.

Huiyan Guo, Xue Dong, Yue Wang, Qingtao Ge, Yimin Tan, Jiaxing Zhang, Xueqing Zhuang, Zhiping Wang, Mengnan An, Zihao Xia and 2 more

Abstract read
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In one paragraph

Article in Plant cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Huiyan Guo *Liaoning Key Laboratory of Plant Pathology, College of Plant Protection, Shenyang Agricultural University, Shenyang, China.
Xue Dong *Liaoning Key Laboratory of Plant Pathology, College of Plant Protection, Shenyang Agricultural University, Shenyang, China.
Yue WangLiaoning Key Laboratory of Plant Pathology, College of Plant Protection, Shenyang Agricultural University, Shenyang, China.
Qingtao GeLiaoning Key Laboratory of Plant Pathology, College of Plant Protection, Shenyang Agricultural University, Shenyang, China.
Yimin TanLiaoning Key Laboratory of Plant Pathology, College of Plant Protection, Shenyang Agricultural University, Shenyang, China.
Jiaxing ZhangLiaoning Key Laboratory of Plant Pathology, College of Plant Protection, Shenyang Agricultural University, Shenyang, China.
Xueqing ZhuangLiaoning Key Laboratory of Plant Pathology, College of Plant Protection, Shenyang Agricultural University, Shenyang, China.
Zhiping WangLiaoning Key Laboratory of Plant Pathology, College of Plant Protection, Shenyang Agricultural University, Shenyang, China.
Mengnan AnLiaoning Key Laboratory of Plant Pathology, College of Plant Protection, Shenyang Agricultural University, Shenyang, China.
Zihao XiaLiaoning Key Laboratory of Plant Pathology, College of Plant Protection, Shenyang Agricultural University, Shenyang, China. zihao8337@syau.edu.cn.ORCID http://orcid.org/0000-0001-7905-106X
Xueqing YangLiaoning Key Laboratory of Plant Pathology, College of Plant Protection, Shenyang Agricultural University, Shenyang, China. xqyang@syau.edu.cn.
Yuanhua WuLiaoning Key Laboratory of Plant Pathology, College of Plant Protection, Shenyang Agricultural University, Shenyang, China. wuyh09@syau.edu.cn.

Funding

the National Key R&D Program of China 2021YFD1400200
6 · The paper itself

Abstract

key messageThis study analyzed the transcriptome, proteome and ubiquitylome of ToBRFV-infected tomato plants and verified the antiviral roles of SlCHS, SlPAO, and SlCCoAOMT in tomato plants through TRV-VIGS assays. Tomato brown rugose fruit virus (ToBRFV) infection causes leaf mottling and fruit wrinkling, significantly affecting tomato quality. Understanding the mechanisms of tomato plants in combating ToBRFV infection is fundamental to the development of effective strategies for viral disease control and management. To investigate the effects of ToBRFV infection on the gene regulatory network of tomato plants, we performed transcriptome, proteome and ubiquitylome sequencing on ToBRFV-infected tomato plants. A total of 874 differentially expressed genes (DEGs) and 675 differentially expressed proteins (DEPs) were identified. Most of them were involved in hormone signal transduction, MAPK signaling pathway, flavonoid biosynthesis, arginine and proline metabolism, and phenylalanine metabolism, and some of these proteins were modified by ubiquitination. Furthermore, virus-induced gene silencing (VIGS) assays revealed that silencing SlCCoAOMT or SlCHS, two flavonoid biosynthesis-related genes, enhanced tomato resistance to ToBRFV infection, while silencing SlPAO, an arginine and proline metabolism-related gene, promoted ToBRFV infection. These results reveal the key regulatory networks of tomato in response to ToBRFV infection, and identify SlCCoAOMT, SlCHS and SlPAO as potential candidate genes for disease-resistant breeding.

Indexed as

Gene Regulatory NetworksPlant DiseasesPlant VirusesSolanum lycopersicumFruitGene Expression ProfilingGene Expression Regulation, PlantGene SilencingMultiomicsPlant ProteinsProteomeTranscriptomePlant ProteinsProteomeProteomeTomatoTomato brown rugose fruit virusTranscriptomeUbiquitylomeVirus-induced gene silencing

Identifiers

PMID41876888

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.