Evidence map›Paper›PMID 41876880›Full record

Trial reportOrthopadie (Heidelberg, Germany)2026

Coronal plane alignment of the knee (CPAK) phenotypes and their relationship with gap patterns in robotic-assisted total knee arthroplasty: a clinical trial.

Filippo Migliorini, Luise Schäfer, Jens Schneider, Andrea Maria Nobili, Daniel Kämmer, Nicola Maffulli, Andreas Bell

Abstract readClinical Trial
In one paragraph

Trial report in Orthopadie (Heidelberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Filippo MiglioriniDepartment of Trauma and Reconstructive Surgery, University Hospital of Halle, Martin-Luther University Halle-Wittenberg, Ernst-Grube-Street 40, 06097, Halle (Saale), Germany. filippo.migliorini@uk-halle.de.
Luise SchäferDepartment of Orthopaedic and Trauma Surgery, Eifelklinik St. Brigida, Kammerbruchstr. 8, 52152, Simmerath, Germany.
Jens SchneiderDepartment of Orthopaedic and Trauma Surgery, Eifelklinik St. Brigida, Kammerbruchstr. 8, 52152, Simmerath, Germany.
Andrea Maria NobiliDepartment of Orthopaedic and Trauma Surgery, Eifelklinik St. Brigida, Kammerbruchstr. 8, 52152, Simmerath, Germany.
Daniel KämmerDepartment of Orthopaedic and Trauma Surgery, Eifelklinik St. Brigida, Kammerbruchstr. 8, 52152, Simmerath, Germany.
Nicola MaffulliDepartment of Trauma and Orthopaedic Surgery, Faculty of Medicine and Psychology, University La Sapienza, 00185, Rome, Italy.
Andreas BellDepartment of Orthopaedic and Trauma Surgery, Eifelklinik St. Brigida, Kammerbruchstr. 8, 52152, Simmerath, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAchieving optimal soft-tissue balance remains a key challenge in total knee arthroplasty (TKA), even with robotic assistance. The coronal plane alignment of the knee (CPAK) classification provides a structured description of constitutional alignment phenotypes, yet its relationship with intraoperative gap behavior has not been fully defined.

methodsA prospective series of 285 patients undergoing robotic-assisted TKA with the CORI system was analyzed. Knees were categorized according to the CPAK classification and intraoperative medial and lateral gaps were automatically recorded in extension (0°) and flexion (90°). Gap configurations were defined as balanced, varus, or valgus. Associations between CPAK phenotypes and gap types were assessed using χ

resultsThe CPAK I and CPAK II phenotypes showed a significantly higher likelihood of varus gaps in both extension (odds ratio, OR 5.41 and 3.38, respectively) and flexion (OR 1.58 and 2.20, respectively), whereas CPAK VII was protective in extension (OR 0.23). Even valgus-aligned phenotypes demonstrated varus-dominant behavior in flexion. These findings indicate that gap behavior is strongly influenced by CPAK phenotype rather than solely by surgical alignment.

conclusionIntraoperative soft-tissue balance during TKA reflects the underlying CPAK phenotype. Integrating CPAK classification into robotic planning enables anticipation of gap tendencies and facilitates phenotype-driven balancing, bridging constitutional anatomy with functional alignment.

Indexed as

Arthroplasty, Replacement, KneeBone MalalignmentKnee JointRobotic Surgical ProceduresAgedFemaleHumansMaleMiddle AgedPhenotypeProspective StudiesRange of Motion, ArticularGap balancingRobotics

Identifiers

PMID41876880
PMCPMC13525067

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.