ArticleHistory and philosophy of the life sciences2026
Sorting out and navigating uncertainty in precision medicine.
Article in History and philosophy of the life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
0 citing papers in PubMed.
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Authors and funding
2 authors.
Funding
Abstract
Uncertainty has been highlighted as a paradoxical consequence of precision medicine (PM). In the life sciences and medicine, uncertainty is often conceptualized as something that can be clearly delimited and overcome by more information and better understanding derived from more research, more data, better tools etc. Building on the observation of uncertainty in PM and exploring it further by differentiating between socio-technical, epistemological and ontological uncertainty, we claim that at least some forms will likely turn out to be non-transient: Uncertainty in PM does not only result from missing or incomplete information, but also from insights into biological complexity and the destabilization of evidence frameworks. We conclude by discussing some implications for a successful implementation of PM in clinical practice by adequately navigating uncertainty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.