Evidence map›Paper›PMID 41876818›Full record

ArticleEMBO reports2026

Cystinosin regulates Na

Veenita Khare, Jean-Claude Farré, Mouad Ait Kbaich, Céline J Rocca, Cynthia Tang, Xuan Ma, Kavya Biederman, Ioli Mathur, Rafael A Badell-Grau, Anusha Sivakumar and 3 more

Abstract read
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In one paragraph

Article in EMBO reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Veenita KhareDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-0677-8967
Jean-Claude FarréDivision of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Mouad Ait KbaichDepartment of Molecular Medicine and Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0001-7508-6935
Céline J RoccaDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-8706-3869
Cynthia TangDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Xuan MaDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-1040-3781
Kavya BiedermanDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.ORCID 0009-0006-0043-4492
Ioli MathurDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.ORCID 0009-0001-8575-8149
Rafael A Badell-GrauDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-7640-822X
Anusha SivakumarDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Rola ChenDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.ORCID 0009-0004-1604-0290
Sergio D CatzDepartment of Molecular Medicine and Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA, USA.
Stephanie CherquiDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA. scherqui@ucsd.edu.ORCID 0000-0003-1240-5219

Funding

Neutrophil Survival and Demise During Inflammatory StatesP01HL152958 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI CATZ, SERGIO DANIEL · 2021 to 2025
$12.4M
Molecular and Cellular Mechanisms of the Lysosomal Storage Disease CystinosisR01DK110162 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI CATZ, SERGIO DANIEL, CHERQUI, STEPHANIE · 2017 to 2025
$4.7M
California Institute for Regenerative Medicine (CIRM) CLIN2-11478 and TRAN1-13983HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) P01HL152958HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK110162HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01-NS108965,R01NS135162,P30-NS047101HHS | NIH | National Institute on Aging (NIA) R01-AG086443Office of Research Infrastructure Programs (ORIP) NIH S10 grant S10OD030417
6 · The paper itself

Abstract

Cystinosis is a systemic lysosomal storage disease resulting from mutations in the CTNS gene encoding the lysosomal cystine transporter cystinosin, leading to cystine accumulation in all organs. Despite cystinosin's ubiquitous expression, renal Fanconi syndrome (FS) is the first clinical manifestation of cystinosis, which is not prevented by cystine reduction therapy with cysteamine. Here, we report a novel interaction of cystinosin and sodium/hydrogen (Na

Indexed as

Amino Acid Transport Systems, NeutralKidney Tubules, ProximalSodium-Hydrogen Exchanger 3AnimalsCystinosisEndosomesHumansMiceMice, KnockoutProtein TransportSodiumAmino Acid Transport Systems, NeutralCTNS protein, humancystinosin protein, mouseSLC9A3 protein, humanSlc9a3 protein, mouseSodiumSodium-Hydrogen Exchanger 3CystinosisHematopoietic Stem and Progenitor CellsNa+/H+ Exchanger 3Proximal Tubular CellsRenal Fanconi Syndrome

Identifiers

PMID41876818
PMCPMC13121807

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.