Evidence map›Paper›PMID 41876812›Full record

ArticleActa neuropathologica2026

Loss of oligodendrocyte transcription factor 2 protein expression in metabolically stressed oligodendrocytes.

Hannes Kaddatz, Lukas Wenzel, Emil Pril, Sophia Meien, Victoria Harz, Luisa Burkert, Newshan Behrangi, Annelie Zimmermann, Linda Frintrop, Sandra Amor and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hannes KaddatzInstitute of Anatomy, Rostock University Medical Center, Gertrudenstr. 9, 18057, Rostock, Germany. hannes.kaddatz@med.uni-rostock.de.
Lukas WenzelInstitute of Anatomy, Rostock University Medical Center, Gertrudenstr. 9, 18057, Rostock, Germany.
Emil PrilInstitute of Anatomy, Rostock University Medical Center, Gertrudenstr. 9, 18057, Rostock, Germany.
Sophia MeienInstitute of Anatomy, Rostock University Medical Center, Gertrudenstr. 9, 18057, Rostock, Germany.
Victoria HarzInstitute of Anatomy, Rostock University Medical Center, Gertrudenstr. 9, 18057, Rostock, Germany.
Luisa BurkertInstitute of Anatomy, Rostock University Medical Center, Gertrudenstr. 9, 18057, Rostock, Germany.
Newshan BehrangiInstitute of Anatomy, Rostock University Medical Center, Gertrudenstr. 9, 18057, Rostock, Germany.
Annelie ZimmermannInstitute of Anatomy, Rostock University Medical Center, Gertrudenstr. 9, 18057, Rostock, Germany.
Linda FrintropInstitute of Anatomy, Rostock University Medical Center, Gertrudenstr. 9, 18057, Rostock, Germany.
Sandra AmorInstitute of Anatomy, Rostock University Medical Center, Gertrudenstr. 9, 18057, Rostock, Germany.
Markus KippInstitute of Anatomy, Rostock University Medical Center, Gertrudenstr. 9, 18057, Rostock, Germany.
Leo HeinigInstitute of Anatomy, Rostock University Medical Center, Gertrudenstr. 9, 18057, Rostock, Germany. leo.heinig@unimedizin-mainz.de.

Funding

FORUN program Rostock University Medical Center #889103FORUN program Rostock University Medical Center #889113Hertie foundation P1250011, DrPrg SoSe 25 Kipp/Pril
6 · The paper itself

Abstract

Oligodendrocytes are essential for myelin production, maintenance, and repair, and their dysfunction contributes to the pathogenesis of demyelinating diseases such as multiple sclerosis (MS). Here, we identify an early stress-associated oligodendrocyte state characterized by a rapid, post-transcriptional loss of the lineage-defining transcription factor Oligodendrocyte Transcription Factor 2 (OLIG2). Using the cuprizone model of toxic demyelination, we observed an early appearance of OLIG2

Indexed as

Oligodendrocyte Transcription Factor 2OligodendrogliaStress, PhysiologicalActivating Transcription Factor 3AnimalsCuprizoneDemyelinating DiseasesDisease Models, AnimalFemaleHumansMaleMiceMice, Inbred C57BLMultiple SclerosisRNA, MessengerSphingosine 1 Phosphate Receptor ModulatorsActivating Transcription Factor 3Atf3 protein, mouseCuprizoneOLIG2 protein, humanOlig2 protein, mouseOligodendrocyte Transcription Factor 2RNA, MessengerSphingosine 1 Phosphate Receptor ModulatorsCuprizoneIntegrated stress responseMultiple sclerosisOLIG2Oligodendrocyte markersOligodendrocytesTranscription factors

Identifiers

PMID41876812
PMCPMC13013231

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.