Evidence map›Paper›PMID 41876707›Full record

ReviewMolecular psychiatry2026

Anesthetics as emerging therapeutics for post-traumatic stress disorder (PTSD): bridging bench and bedside.

Xinchun Mei, Haitao Wu, Tifei Yuan, James N Samsom, Siqi Ying, Xin Liu, Tianle Xu, Fang Liu, Yuan Shen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xinchun MeiDepartment of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Haitao WuDepartment of Neurobiology, Beijing Institute of Basic Medical Sciences, Beijing, 100850, China.ORCID http://orcid.org/0000-0001-8437-3194
Tifei YuanShanghai Key Laboratory of Psychotic Disorders, Brain Health Institute, National Center for Mental Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine and School of Psychology, Shanghai, 200030, China.ORCID http://orcid.org/0000-0003-0510-715X
James N SamsomCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 250 College St., Toronto, M5T 1R8, Ontario, Canada.
Siqi YingDepartment of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Xin LiuDepartment of Psychiatry, Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.
Tianle XuDepartment of Anesthesiology, Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders (LEAD), Shanghai, 201620, China.ORCID http://orcid.org/0000-0002-1438-0038
Fang LiuInstitute of Mental Health and drug discovery, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Psychiatry, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.ORCID http://orcid.org/0000-0002-5414-4160
Yuan ShenDepartment of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China. kmshy@tongji.edu.cn.ORCID http://orcid.org/0000-0002-7811-1478

Funding

Chinese Ministry of Science and Technology | Department of S and T for Social Development (Department of S&T for Social Development) 2021ZD0202003
6 · The paper itself

Abstract

Post-traumatic stress disorder (PTSD) is a severe psychiatric disorder that develops in the months and years following exposure to severe trauma. Despite growing research, there remain gaps in understanding the full pathophysiology of PTSD, so that treatments are not universally effective, contributing to a significant public health burden. Therefore, it is necessary to explore novel therapeutic approaches. Anesthetics have recently been shown as a novel therapeutic agent with promising results in the treatment of PTSD. This review summarizes key mechanisms of anesthetics, including N-methyl-D-aspartate (NMDA) receptor antagonists, α2-adrenergic receptor agonists, Gamma-Aminobutyric Acid (GABA)-A Receptor-related anesthetics and opioids, and their translational potential to treatment of PTSD.

Indexed as

AnestheticsStress Disorders, Post-TraumaticAdrenergic alpha-2 Receptor AgonistsAnalgesics, OpioidAnimalsGABA AgentsHallucinogensHumansReceptors, N-Methyl-D-AspartateTranslational Research, BiomedicalAdrenergic alpha-2 Receptor AgonistsAnalgesics, OpioidAnestheticsGABA AgentsHallucinogensReceptors, N-Methyl-D-Aspartate

Identifiers

PMID41876707

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.